Antidepressants as a New Approach for Protective Interventions of Cisplatin-Induced Nephrotoxicity
Amr A EL-Arabey* and Adel R Abd-Allah
Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
- *Corresponding Author:
- Amr A EL-Arabey
Pharmacology and Toxicology Department
Faculty of Pharmacy, Al-Azhar University
Nasr City, Cairo, Egypt
Tel: +39 0187533213
E-mail: [email protected]
Received date: September 16, 2015; Accepted date: October 20, 2015; Published date: October 26, 2015
Citation: EL-Arabey AA, Abd-Allah AR (2015) Antidepressants as a New Approach for Protective Interventions of Cisplatin-Induced Nephrotoxicity. J Kidney 1:102. doi:10.4172/2472-1220.1000102
Copyright: © 2015 EL-Arabey AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cisplatin is a chemotherapy drug that is used to treat different types of cancer, including testicular cancer, germ cell cancer, bladder cancer, cervical cancer, small cell and non-small cell lung cancer, head and neck cancer and others. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. Organic cation transporter-2 is responsible for cisplatin uptake in the kidney. In this article we will underline the use of antidepressant as a new approach for protective interventions of cisplatin-induced nephrotoxicity through the interference of cisplatin uptake by Organic Cation Transporter-2 to improve the therapeutic index of cisplatin and to treat depression which occurs in cancer patients together after considering the risk of side effects and interactions.