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ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Anti-diabetes and Anti-inflammatory Activities of Phenolic Glycosides from Liparis odorata

Hongdong Liu1,2, Bin Li1*, Piao Jiang1, Youquan Zhong1, Dongming Zhang3, Hua Liu1, Pingnan Wan1, Xuewen Lai1, Bo Liu1 and Jie Chen1

1Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China

2Technology Center, Jiangzhong Group, 618 Huoju Road, Nanchang 330096, Jiangxi, PR China

3Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China

*Corresponding Author:
Bin Li
Pharmacy College, Jiangxi University of Traditional Chinese Medicine
818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Tel: 8679187118827
Fax: 8679187118825
E-mail: [email protected]

Received Date: July 06, 2016; Accepted Date: July 14, 2016; Published Date: July 20, 2016

Citation: Liu H, Li B, Jiang P, Zhong Y, Zhang D, et al. (2016) Anti-diabetes and Anti-inflammatory Activities of Phenolic Glycosides from Liparis odorata. Med chem (Los Angeles) 6:500-505. doi:10.4172/2161-0444.1000390

Copyright: © 2016 Liu H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Five new phenolic glycosides, liparisglycoside K-O (1-5) and one known compound, 4-allyl-2,6-dimethoxyphenol glucoside (6) were isolated from the whole plant of Liparis odorata. Compound 6 was isolated and identified from this genus for the first time. The structures of all compounds were elucidated through extensive spectroscopic methods including UV, IR, MS, 1D- and 2D-NMR. All compounds from Liparis odorata were evaluated for their ability to inhibit LPS-induced NO production on the BV2 microglial cell line in vitro, as well as their inhibitory effects on PTP1B and α-glucosidase enzyme assays.

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