Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats
- *Corresponding Author:
- Osama Mohamed Ahmed
Zoology Department (Physiology Division)
Faculty of Science, Beni-Suef University, Egypt
E-mail: [email protected]
Received date: January 26, 2012; Accepted date: February 23, 2012; Published date: February 24, 2012
Citation: Ahmed OM, Hussein AM, Ahmed RR (2012) Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A]Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats. Med chem 2:020-028. doi:10.4172/2161-0444.1000108
Copyright: © 2012 Ahmed OM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Synthesis of some novel pyrimido[1,6-a]pyrimidine derivatives 4, 8 and 10 was described through the respective reactions of sodium salts of formyl ketones 1, 7 and 9 with 6-aminothiouracil. The characterization of the reaction products was confirmed by using the available elemental analysis and spectral data. One of these derivatives (4b), 1-thioxo-1,2,7,8,9,10-hexahydro-3H-pyrimido[1,6-a]quinazolin-3-one, was tested using sublethal dose level (10 mg/kg b. w./day for 3 weeks) and was found to have potent antihyperglycemic, antihyperlipidemic and antioxidant properties in neonatal streptozotocin-induced (n-STZ) diabetic male and female albino rats.