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ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Research Article

Antidiabetic and Antioxidant Properties of Copper Nanoparticles Synthesized by Medicinal Plant Dioscorea bulbifera

Sougata Ghosh1,2, Piyush More1, Rahul Nitnavare1, Soham Jagtap1, Rohan Chippalkatti1, Abhishek Derle1, Rohini Kitture3, Adersh Asok4, Sangeeta Kale3, Shailza Singh5, Mahemud L Shaikh5, Boppana Ramanamurthy5, Jayesh Bellare6 and Balu A Chopade7*

1Institute of Bioinformatics and Biotechnology, University of Pune, Pune-411007, India

2Department of Microbiology, Modern College of Arts, Science and Commerce, Ganeshkhind, Pune-411016, India

3Department of Applied Physics, Defense Institute of Advanced Technology, Girinagar, Pune-411025, India

4The Centre for Research in Nanotechnology and Science (CRNTS), Indian Institute of Technology Bombay, Powai, Mumbai 400076, India

5National Centre for Cell Science, University of Pune Campus, Ganeshkhind, Pune-411007, India

6Department of Chemical Engineering, Indian Institute of Technology, Bombay, Powai, Mumbai-400076, India

7Department of Microbiology, University of Pune, Pune-411007, India

*Corresponding Author:
Balu A Chopade
Professor, Department of Microbiology
University of Pune, Pune 411007, India
Tel: +91 020 25690643
Fax: +91 020 25690087
E-Mail: [email protected]

Received Date: August 25, 2015 Accepted Date: September 22, 2015 Published Date: September 30, 2015

Citation: Ghosh S, More P, Nitnavare R, Jagtap S, Chippalkatti R, et al. (2015) Antidiabetic and Antioxidant Properties of Copper Nanoparticles Synthesized by Medicinal Plant Dioscorea bulbifera. J Nanomed Nanotechnol S6:007. doi:10.4172/2157-7439.S6-007

Copyright: © 2015 Ghosh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Biological route for synthesis of copper nanoparticles (CuNPs) with therapeutic potential is a major challenge. In this study, CuNPs were synthesized by D. bulbifera tuber extract (DBTE) which were further evaluated for antidiabetic and free radical scavenging activity.

Methods: CuNPs synthesized by DBTE were characterized by UV-visible spectroscopy, transmission electron microscopy, energy dispersive spectroscopy and dynamic light scattering. CuNPs were checked for α-amylase and α-glucosidase inhibition along with interaction studies employing fluroscence spectroscopy, circular dichroism spectroscopy and computational docking. DPPH, nitric oxide and superoxide radical scavenging activities of CuNPs were also checked.

Results: Spherical monodispersed CuNPs were synthesized within 5 h that was indicated by a colour change from pale blue to brown. Majority of the nanoparticles synthesized were found to be between 12 to 16 nm as showed in DLS which grew till a final size of 86 to 126 nm as indicated in TEM. Bioreduced CuNPs showed 38.70 ± 1.45% and 34.72 ± 1.22% inhibition against porcine and murine pancreatic amylase, respectively with an uncompetitive mode that was further confirmed by docking studies. Fluorescence spectroscopy confirmed the interaction of CuNPs to the enzyme via Trp residues while CD spectra indicated the structural and conformational changes on binding of CuNPs to the enzyme. CuNPs exhibited 99.09 ± 0.15% inhibition against α-glucosidase while 90.67 ± 0.33% inhibition against murine intestinal glucosidase, respectively. CuNPs showed 40.81 ± 1.44%, 79.06 ± 1.02% and 48.39 ± 1.46% scavenging activity against DPPH, nitric oxide and superoxide radicals respectively.

Conclusion: D.bulbifera tuber extract mediated bioreduction is most rapid route to synthesize novel CuNPs with promising antidiabetic and antioxidant properties. This is the first detailed report which provides intense scientific rationale for the use of CuNPs as nanomedicine for efficient control of T2DM and oxidative stress.


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