alexa Anti-Diarrheal and Anti-Nociceptive Effects of a Hydroe
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

Anti-Diarrheal and Anti-Nociceptive Effects of a Hydroethanolic Leaf Extract of Walnut in Rats

Sophie Holowacz1*, Claude Blondeau1, Isabelle Guinobert1, Angèle Guilbot1, Valérie Bardot2, César Cotte2, Isabelle Ripoche3, Pierre Chalard3, Sophie Hidalgo-Lucas4 and Jean-François Bisson4

1PiLeJe, 37 Quai de Grenelle, 75015 Paris Cedex 15, France

23i Nature, Naturopôle, Les Tiolans, 03800 Saint-Bonnet de Rochefort, France

3Sigma Clermont, Campus des Cézeaux, 63178 Aubière Cedex, France

4Etap-Lab, 13 Rue du Bois de la Champelle, 54500 Vandoeuvre-lès-Nancy, France

*Corresponding Author:
Sophie Holowacz
PiLeJe, 37 Quai de Grenelle, 75015 Paris Cedex 15, France
Tel: +33153867072
Fax: +33156580144
E-mail: [email protected]

Received date: August 30, 2016; Accepted date: September 16, 2016; Published date: September 21, 2016

Citation: Holowacz S, Blondeau C, Guinobert I, Guilbot A, Bardot V, et al. (2016) Anti-Diarrheal and Anti-Nociceptive Effects of a Hydroethanolic Leaf Extract of Walnut in Rats. Med Aromat Plants (Los Angel) 5:268. doi: 10.4172/2167- 0412.1000268

Copyright: © 2016 Holowacz S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Juglans regia L. (walnut) is a plant traditionally used for the treatment of diarrhea. We investigated the antidiarrheal effects of a hydroethanolic leaf extract (HLE) of J. regia against castor oil-induced diarrhea in rats after screening phenolic compounds in the extract. J. regia HLE (0.5, 1, and 2 g/kg by gavage) produced a dose-dependent delay in the onset of diarrhea compared to the vehicle. It also significantly reduced the number of diarrheal feces, fresh weight and water content of the feces, body weight loss and pain at the two highest doses. Loperamide was effective in inhibiting diarrhea and body weight loss but failed to reduce pain. Our findings show that J. regia HLE has a beneficial effect on diarrhea symptoms and associated pain suggesting that it could be an interesting alternative to standard anti-motility drugs. Flavonoids and hydroxycinnamic acids detected in the extract might explain the effects observed.


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