Antifertility Activity in the Acetone Extracts of Datura metel, L Seeds on Female MousePandiarajan G1, Govindaraj R2, Makesh kumar B1 and Sankarasivaraman K3*
- *Corresponding Author:
- Dr. K. Sankarasivaraman
Centre for Research and Post Graduate Studies in Botany
Ayya Nadar Janaki Ammal College, Sivakasi, Tamil Nadu, India
E-mail: [email protected]
Received date: May 28, 2012; Accepted date: July 20, 2012; Published date: July 25, 2012
Citation: Pandiarajan G, Govindaraj R, Makesh Kumar B, Sankarasivaraman K (2012) Antifertility Activity in the Acetone Extracts of Datura metel, L Seeds on Female Mouse. J Pharmacogenomics Pharmacoproteomics 3: 111. doi: 10.4172/2153-0645.1000111
Copyright: © 2012 Pandiarajan G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study shows the antifertility activity in the acetone extracts of Datura metal L. in female albino
mouse. The crude extract of Datura metel seeds were administered orally to the female mouse (25 gm of bodyweight) in the concentration of 0.5%, 1% and 2% respectively. Control was maintained using NaCl solution. After 15th day of treatment the female mouse was mated with the normal male mouse in the ratio of 1:3. After 10 days of mating they were dissected and observed the number of implantation sites in the uterine horns. The results stated that the females treated with 2% seed extracts caused cent percent anti-implantation activity followed by 1% and 0.5% seed extracts caused 40% and 80% anti implantation activity respectively. The results of the present study concludes that the seed extracts of Datura metel L may be recommended as a good source of antifertility inducious compounds with minimal side effects after testing in the other human models.