alexa Antifungal Activities and Preliminary Phytochemical Investigation of Combretum Species from Zimbabwe
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
Open Access

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Research Article

Antifungal Activities and Preliminary Phytochemical Investigation of Combretum Species from Zimbabwe

Rumbidzai Mangoyi1, Washington Mafukidze1, Kerstin Marobela2 and Stanley Mukanganyama1*

1Biomolecular Interactions Analyses Laboratory, Department of Biochemistry, University of Zimbabwe, P.O. Box MP167, Mount Pleasant, Harare, Zimbabwe

2Department of Biological Sciences, University of Botswana, Gaborone, Botswana

*Corresponding Author:
Dr. Stanley Mukanganyama
Department of Biochemistry
University of Zimbabwe
P.O. Box MP 167 Mt. Pleasant Harare, Zimbabwe
Tel: 263-4-2917638
E-mail: [email protected]

Received Date: December 19, 2011; Accepted Date: March 14, 2012; Published Date: March 19, 2012

Citation: Mangoyi R, Mafukidze W, Marobela K, Mukanganyama S (2012) Antifungal Activities and Preliminary Phytochemical Investigation of Combretum Species from Zimbabwe. J Microbial Biochem Technol 4: 037-044. doi: 10.4172/1948-5948.1000069

Copyright: © 2012 Mangoyi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Aeromonas hydrophila is one of the serious pathogens in ornamental fishes causing hemorrhagic bacterial
septicemia leading to inflammation and necrosis of the gastrointestinal tract, kidney, muscle, and spleen. Recent studies demonstrated that immunoproteomic vaccines provide protection against bacterial pathogens in fin fish aquaculture and the vaccines are popular due to its long lasting immunity, safety and low cost versatile characteristics. In this study we used an Outer Membrane Protein (OMP) of Aeromonas hydrophila as a vaccine to provide protection against the pathogen in goldfish (Carassius auratus). We used the extract of Asparagus racemosus as an adjuvant in the vaccine preparation. Surivival and immunological response of the vaccinated fishes (30 and 60 days post vaccination (dpv)), were evaluated after challenge with virulent A. hydrophila. The vaccine treated experimental groups significantly improved (P<0.05) the survival at 50% compared to the controls and had improved immunological responses including phagocytosis, albumin-globulin ratio, serum bactericidal activity, and serum lysozyme activity.

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