alexa Antifungal Potential of Marine Sponge Extract against P
ISSN: 2572-3103

Journal of Oceanography and Marine Research
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Research Article

Antifungal Potential of Marine Sponge Extract against Plant and Fish Pathogenic Fungi

Prabha Devi1*, Ravichandran S2, Ribeiro M1 and Ciavatta ML3
1Chemical Oceanography Division, National Institute of Oceanography, CSIR, Dona Paula Goa 403004, India
2Center of Advanced Study in Marine Biology, Annamalai University, Parangipettai 608502, India
3Consiglio Nazionale delle Ricerche, Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei 34-Comprensorio Olivetti 80078, Pozzuoli, Napoli, Italy
Corresponding Author : Prabha Devi
Chemical Oceanography Division
National Institute of Oceanography
CSIR, Dona Paula Goa 403004 India
E-mail: [email protected]
Received August 20, 2013; Accepted September 18, 2013; Published September 23, 2013
Citation: Devi P, Ravichandran S, Ribeiro M, Ciavatta ML (2013) Antifungal Potential of Marine Sponge Extract against Plant and Fish Pathogenic Fungi. Oceanography 1:112. doi: 10.4172/2332-2632.1000112
Copyright: © 2013 Devi P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The need for discovery of new antibiotics is imperative because previous evidence suggest that development of resistance to any new antimicrobial agents is inevitable. In addition, compounds not tested for antimicrobial activity also gives ample scope for rediscovering compounds with antimicrobial activity. This study screens extracts (Diethyl Ether and Butanol) of a marine red-Sea sponge Negombata magnifica for in vitro fungicidal activity against 10 plant and 3 fish pathogens. Fungicidal activity of the crude diethylether fraction of the sponge against test strains showed exceptionally high activity against three virulent fish pathogens Exophiala salmonis, Branchiomyces demigrans and Saprolegnia sp. Furthermore, Minimal Inhibitory Concentration (MIC) of the compound was evaluated with respect to Exophiala salmonis (1.5 μg/ml) Branchiomyces demigrans (0.75 μg/ml) and Saprolegnia sp. (3 μg/ml) respectively. Finally, bioassay guided isolation and purification led to the identification of the active compound as latrunculin B on the basis of spectroscopic data. This finding suggests that latrunculin B, could be considered as a lead molecule for the design of new antifungals for managing common fungal diseases in aquaculture. Toxicity testing of this compound on shrimps indicated that the compound was non toxic up to a concentration as high as 5 mg/ml suggesting its suitability for use in aquaculture.


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