Anti-Hyperglycemic and Antioxidant Effect of Saraca asoca (Roxb. De Wilde) Flowers in Streptozotocin-Nicotinamide Induced Diabetic Rats: A Therapeutic Study
- *Corresponding Author:
- Shanti Bhushan Mishra
Department of Pharmacognosy
United Institute of Pharmacy,
Allahabad -211010, India
Fax: 91(0532) 2687142
Received Date: October 06, 2014; Accepted November 27, 2014; Published November 29, 2014
Citation: Mishra SB, Vijayakumar M (2014) Anti-Hyperglycemic and Antioxidant Effect of Saraca asoca (Roxb. De Wilde) Flowers in Streptozotocin-Nicotinamide Induced Diabetic Rats: A Therapeutic Study. J Bioanal Biomed S12:003. doi: 10.4172/1948-593X.S12-003
Copyright: © 2014 Mishra SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
50% Ethanolic extract of Saraca asoca Roxb. de Wilde flowers (SAE) was screened for its antihyperglycemic and antioxidant effect in streptozotocin-nicotinamide induced diabetic rats. Phytochemical analysis of SAE revealed the presence of phenolic compounds phytosterol, flavonoids and saponins. After the administration of extract 200 mg/kg body weight/day) in diabetic rats has improved the elevated levels of blood glucose (p<0.01). The decreased activities of key antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione in diabetic rats were brought back to near normal range upon SAE treatment. Our studies demonstrate the anti-hyperglycemic and anti-oxidative potential of Saraca asoca which could exert sympathetic effects against the diabetes and associated free radicals complications.