alexa Anti-Hyperglycemic and Antioxidant Effect of Saraca asoca (Roxb. De Wilde) Flowers in Streptozotocin-Nicotinamide Induced Diabetic Rats: A Therapeutic Study
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
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Research Article

Anti-Hyperglycemic and Antioxidant Effect of Saraca asoca (Roxb. De Wilde) Flowers in Streptozotocin-Nicotinamide Induced Diabetic Rats: A Therapeutic Study

Shanti Bhushan Mishra1* and Vijayakumar M2

1Department of Pharmacognosy, United Institute of Pharmacy, Allahabad, India

2The Himalaya Drug Company, Bangalore, India

*Corresponding Author:
Shanti Bhushan Mishra
Assistant professor
Department of Pharmacognosy
United Institute of Pharmacy,
Allahabad -211010, India
Tel.: +918004279457
Fax: 91(0532) 2687142
E-mail:[email protected]

Received Date: October 06, 2014; Accepted November 27, 2014; Published November 29, 2014

Citation: Mishra SB, Vijayakumar M (2014) Anti-Hyperglycemic and Antioxidant Effect of Saraca asoca (Roxb. De Wilde) Flowers in Streptozotocin-Nicotinamide Induced Diabetic Rats: A Therapeutic Study. J Bioanal Biomed S12:003. doi: 10.4172/1948-593X.S12-003

Copyright: © 2014 Mishra SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

50% Ethanolic extract of Saraca asoca Roxb. de Wilde flowers (SAE) was screened for its antihyperglycemic and antioxidant effect in streptozotocin-nicotinamide induced diabetic rats. Phytochemical analysis of SAE revealed the presence of phenolic compounds phytosterol, flavonoids and saponins. After the administration of extract 200 mg/kg body weight/day) in diabetic rats has improved the elevated levels of blood glucose (p<0.01). The decreased activities of key antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione in diabetic rats were brought back to near normal range upon SAE treatment. Our studies demonstrate the anti-hyperglycemic and anti-oxidative potential of Saraca asoca which could exert sympathetic effects against the diabetes and associated free radicals complications.

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