alexa Anti-Inflammatory Activity and Cytotoxicity of the Star
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Anti-Inflammatory Activity and Cytotoxicity of the Starfish Extracts on Cancer Cells in Culture

Jumeri Mangun Wikarta1,2 and Sang Moo Kim2*

1Department of Agroindustrial Technology, Faculty of Agricultural Technology, Gadjah Mada University, Bulaksumur, Yogyakarta, Indonesia

2Department of Marine Food Science and Technology, Gangneung, Wonju National University, Gangneung 210-702, Republic of Korea

*Corresponding Author:
Sang Moo Kim
Department of Marine Food Science and Technology
Gangneung, Wonju National University
Gangneung 25457, Republic of Korea
Tel: +82336402343
Fax: +82336402850
E-mail: [email protected]

Received date: May 03, 2016; Accepted date: May 13, 2016; Published date: May 18, 2016

Citation: Wikarta JM, Kim SM (2016) Anti-Inflammatory Activity and Cytotoxicity of the Starfish Extracts on Cancer Cells in Culture. Med chem (Los Angeles) 6: 331- 338. doi:10.4172/2161-0444.1000366

Copyright: © 2016 Wikarta JM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: The starfishes were shown to containe the bioactive compounds which exhibit various biological activities including cytotoxicity, antiinflammatory, hemolytic, antibacterial, antiviral, and antifungal effects.

Objective: To determine the anti-inflammatory activity and cytotoxicity of the extracts of four different starfishes.

Materials and methods: The homogenized fresh body component of starfishes were extracted and concentrated. The EtOH extract of A. pectinifera with high extraction yield and total phenol was partitioned using different extraction solvents. The CHCl3 fraction was further fractionated using thin-layer chromatography, silica-gel chromatography, gel filtration, and recycling preparative HPLC, in that order.

Results: Fraction SAP4.2.5 exhibited strong anti-inflammatory activity without cytotoxic effect up to a concentration of 25 μg/mL, and high cytotoxicity, with IC50 values of 19.4, 34.8, and 32.7 μg/mL against AGS, DLD-1, and HeLa cells, respectively. These biological activities could be due to the presence of lathosterol, 13-tetradecen-1-ol acetate, and stigmast-7-en-3-ol (3ß,5α,24S)-like compounds.

Conclusion: Starfish has a great potential as a resource for natural health products because of its strong antiinflammatory and anticancer activities.

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