alexa Anti-Inflammatory Cytokines in Sepsis: Immunological St
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
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Review Article

Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation

Gomes AP1, Alves DLS1, Miguel PSB1, Inoue VH2, Correia Lopes TC1, Santana LA1, Geller M3 and Siqueira-Batista R1,4

1Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa- UFV-Viçosa (MG), Brasil.

2Departamento de Informática, Universidade Federal de Viçosa - UFV-Viçosa (MG), Brasil.

3School of Medicine, New York University - NYU, New York, USA.

4Núcleo de Estudos em Ciências Médicas (NUMED), Faculdade Dinâmica do Vale do Piranga, FADIP, Ponte Nova (MG), Brasil.

*Corresponding Author:
Andréia Patrícia Gomes
Departamento de Medicina e Enfermagem
Universidade Federal de Viçosa, Avenida P. H. Rolfs, s/n
Campus Universitário, CEP: 36571-000 - Viçosa (MG), Brasil
Tel: (31) 3899-3978
E-mail: [email protected]

Received date: June 10, 2016; Accepted date: July 28, 2016; Published date: August 12, 2016

Citation: Gomes AP, Alves DLS, Miguel PSB, Inoue VH, Correia Lopes TC et al. (2016) Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation. J Pharma Care Health Sys 3:166. doi:10.4172/2376-0419.1000166

Copyright: © 2016 Gomes AP et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The pathophysiology, diagnosis, treatment and prognosis of sepsis remain major challenges for contemporary clinical practice. In this sense, efforts to broaden the knowledge about the mechanisms involved in systemic inflammation and to identify new methods for detecting sepsis in the early stages and the stratification of patients are extremely important. The purpose of this paper is to review the role of the anti-inflammatory cytokines in sepsis and present perspectives on the in silico investigation of the role of these mediators in this nosological entity, using the computational system AutoSimmune.


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