Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae)
- *Corresponding Author:
- Gustav Komlaga
Department of Pharmacognosy
Kwame Nkrumah University of Science and Technology
E-mail: [email protected]
Received Date: July 10, 2017; Accepted Date: July 28, 2017; Published Date: July 31, 2017
Citation: Dade J, Kablan L, Attioua B, Bories C, El Hadji Bamba S, et al. (2017) Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae). J Pharmacogn Nat Prod 3:136. doi: 10.4172/2472-0992.1000136
Copyright: © 2017 Dade J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Leishmaniasis and trypanosomiasis are protozoan diseases caused respectively by the kinetoplastid protozoan Leishmania parasites transmitted by the female phlebotomine sandflies and Trypanosoma parasites transmitted by the tsetse fly. In the search for agents from tropical medicinal plants to treat these two neglected tropical diseases, serially extracted petroleum ether, dichloromethane and methanol extracts of the leaves of Monodora crispata and Monodora brevipes, and eleven aporphines alkaloids isolated from the dried powdered leaves of the two plants were evaluated against Leishmania donovani promastigotes and Trypanosoma brucei brucei trypomastigotes. The extracts of both plants and the isolated compounds displayed varied levels of antiprotozoal activities. The oxoaporphine compounds, (+)-anolobine (7) and (+)-listeferine (8), exerted the most significant activity against L. donovani (IC50: 14.59 μM) and T. brucei brucei (LC100: 50.02 μM) respectively. This is the first report on the antiprotozoal activity of the isolated compounds. The results offer potential for further studies of the oxoaporphines for enhanced antiprotozoal activity.