alexa Anti-malarial Activity of New Emodin Derivatives against Plasmodium falciparum Chloroquine Resistant Strain | OMICS International | Abstract
ISSN: 2329-6836

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Research Article

Anti-malarial Activity of New Emodin Derivatives against Plasmodium falciparum Chloroquine Resistant Strain

Sukanya Pandeti1, Sarika Gunjan2, Sandeep Paidipelli1, Renu Tripathi2 and Narender Tadigoppula1*
1Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226 031, U.P India
2Parasitology Division, CSIR-Central Drug Research Institute, Lucknow-226 031, U.P, India
Corresponding Author : Narender Tadigoppula
Medicinal and Process Chemistry Division
CSIR - Central Drug Research Institute
Lucknow-226031, U.P, India
Tel: +91-5222612411
Fax: +91-5222623405
E-mail: [email protected]
Received September 18, 2014; Accepted September 26, 2014; Published September 28, 2014
Citation: Pandeti S, Gunjan S, Paidipelli S, Tripathi R, Tadigoppula N (2014) Anti-malarial Activity of New Emodin Derivatives against Plasmodium falciparum Chloroquine Resistant Strain. Nat Prod Chem Res 2:150. doi: 10.4172/2329-6836.1000150
Copyright: 2014 Pandeti S, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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Abstract

Emodin (1) is the major bioactive compound of several herb species, which belongs to anthraquinone class of compound. As a part of our drug discovery program, large quantities of emodin (1) was isolated from the roots of Rheum emodi and a library of novel emodin derivatives 2–24 were prepared to evaluate their in-vitro antimalarial activity, among them, compound 17, 18 and 20 showed potent antimalarial activity against chloroquine resistant strain PfK1with the IC50 of 2.28, 2.49 and 2.48 μM respectively with a high safety index.

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