Antimalarial and Anti-Hemolytic Properties of Aqueous Crude Extract of Gynostemma pentaphyllum Leaves against Plasmodium berghei Infection in MiceVoravuth Somsak*, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, Butsarat Saiphet and Preeyanuch Borkaew
Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, Thailand
- *Corresponding Author:
- Voravuth Somsak
Department of Clinical Chemistry, Faculty of Medical Technology
Western University, Kanchanaburi 71170, Thailand
E-mail: [email protected]
Received Date: September 21, 2016; Accepted Date: October 04, 2016; Published Date: October 14, 2016
Citation: Somsak V, Klubsri C, Kittiyaporn D, Bootprom P, Saiphet B, et al (2016) Antimalarial and Anti-Hemolytic Properties of Aqueous Crude Extract of Gynostemma pentaphyllum Leaves against Plasmodium berghei Infection in Mice. Malaria Contr Elimination 5: 150. doi: 10.4172/2470-6965.1000150
Copyright: © 2016 Somsak V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Continuous emergence of antimalarial drug resistant malaria parasites warrant urgent search for new antimalarials. Traditional medicinal plant extracts have been the main sources for screening antimalarial activity. Accordingly, this study was aimed at investigation the antimalarial and anti-hemolytic properties of aqueous crude extract of Gynostemma pentaphyllum leaves against Plasmodium berghei infected mice. Aqueous crude extract of G. pentaphyllum leaves have been prepared and tested for acute toxicity and antimalarial efficacy in P. berghei ANKA infected mice. At three oral doses of 100, 500 and 1,000 mg/kg of extract were safe, chemosuppressive and thus prevented packed cell volume reduction in a dose-dependent manner compared to the untreated control group. The maximum efficacy was found at the dose of 1,000 mg/kg. This study suggests that the aqueous crude extract of this plant have promising antimalarial activity against P. berghei in a dose-dependent manner, which supports the traditional use of this plant for malaria treatment.