alexa Antimalarial and Anti-hypoglycemic Properties of Siamese Neem Tree (Azadirachta indica) in Plasmodium berghei Infected Mice
ISSN: 2470-6965

Malaria Control & Elimination
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Research Article

Antimalarial and Anti-hypoglycemic Properties of Siamese Neem Tree (Azadirachta indica) in Plasmodium berghei Infected Mice

Voravuth Somsak*, Sukanya Chachiyo, Jutatip Kittitorn, Suthin Audomkasok and Sairung Sriwiphat

Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, Thailand

*Corresponding Author:
Voravuth Somsak
Department of Clinical Chemistry
Faculty of Medical Technology, Western University
Kanchanaburi 71170, Thailand
Tel: +66898009939
E-mail: [email protected]

Received August 11, 2015; Accepted September 24, 2015; Published October 01, 2015

Citation: Somsak V, Chachiyo S, Kittitorn J, Audomkasok S, Sriwiphat S (2015) Antimalarial and Anti-hypoglycemic Properties of Siamese Neem Tree (Azadirachta indica) in Plasmodium berghei Infected Mice. Malar Cont Elimination 4:134. doi: 10.4172/2470-6965.1000134

Copyright: © 2015 Somsak V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



The present study has been carried out to investigate antimalarial and anti-hypoglycemic activities of leaf aqueous crude extract of Siamese neem tree (Azadirachta indica) against Plasmodium berghei infected mice. Groups of ICR mice were treated orally with Siamese neem tree extract (500, 1000, and 2000 mg/kg) after infection with P. berghei ANKA. Parasitemia and blood glucose levels were determined. At these doses, Siamese neem tree extract inhibited parasitemia in dose-dependent manner with significance (P < 0.05). In addition, anti-hypoglycemic activity has been observed in infected mice treated with Siamese neem tree extracts. In particularly, the highest activities of Siamese neem tree extract were found at dose 2000 mg/kg. These results indicated that leaf aqueous crude extract of Siamese neem tree have antimalarial and anti-hypoglycemic activities against P. berghei ANKA infected mice.


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