alexa Antimicrobial Peptidesas an Alternative Approach to Tre
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Antimicrobial Peptidesas an Alternative Approach to Treat Bacterial Infections

Hervé Le Moual*, Jenny-Lee Thomassin and John R Brannon
Department of Microbiology and Immunology, and Faculty of Dentistry, McGill University, Montreal, QC, H3A 2B4, Canada
Corresponding Author : Hervé Le Moual
Department of Microbiology and Immunology
McGill University, 3775 University Street
Montreal, QC, H3A 2B4, Canada
Tel: 5143986235
Fax: 5143987052
E-mail: [email protected]
Received May 31, 2013; Accepted July 25, 2013; Published July 30, 2013
Citation: Moual HL, Thomassin JL, Brannon JR (2013) Antimicrobial Peptidesas an Alternative Approach to Treat Bacterial Infections. J Clin Cell Immunol S13:004. doi:10.4172/2155-9899.S13-004
Copyright: © 2013 Moual HL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The spread of antibiotic resistance genes amongst microbes, the emergence of multi-drug resistant bacterial pathogens and the paucity of antibiotics in development have caused a major health care crisis. With few options available to treat multi-drug resistant bacteria, it is critical to develop alternative therapies to conventional antibiotics. An auspicious alternative strategy stems from antimicrobial peptides (AMPs), which are the host’s own “endogenous antibiotics”. AMPs are produced at mucosal surfaces, where they exert both bactericidal and immunomodulatory activities making them important components of the innate immune system. To date, the development of AMPbased therapies has focused on developing synthetic peptides with tailored activity and boosting endogenous AMP-expression. These therapies may be confounded by the multiple bacterial AMP-resistance mechanisms that have arisen during the co-evolution of bacteria with their hosts’ innate immune system. Therefore, approaches that counteract bacterial AMP-resistance mechanisms can be added to the arsenal of novel therapies. This review provides an overview of human AMPs and summarizes the current strategies used to develop AMP-based therapies with particular focus on a novel strategy that aims to boost AMP activity by inhibiting bacterial AMP-resistance mechanisms.

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