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Antimicrobial Pharmacokinetics and Pharmacodynamics in the Treatment of Nosocomial Gram-negative Infections | OMICS International | Abstract
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
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Review Article

Antimicrobial Pharmacokinetics and Pharmacodynamics in the Treatment of Nosocomial Gram-negative Infections

Raymond Cha1,2*, Sarah M. Michienzi1 and Lama Hsaiky1,2
1Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, Michigan 48201, USA
2Oakwood Healthcare System, 18101 Oakwood Blvd., Dearborn, Michigan 48124, USA
*Corresponding Author : Raymond Cha, Pharm.D
Eugene Applebaum College of Pharmacy and Health Sciences
259 Mack Ave. Detroit
Michigan 48201, USA
Tel: 313-577-5303
E-mail: [email protected]
Received October 09, 2012; Accepted October 29, 2012; Published October 31, 2012
Citation: Cha R, Michienzi SM, Hsaiky L (2012) Antimicrobial Pharmacokinetics and Pharmacodynamics in the Treatment of Nosocomial Gram-negative Infections. Adv Pharmacoepidem Drug Safety S1:005. doi:10.4172/2167-1052.S1-005
Copyright: © 2012 Cha R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


While infections due to multidrug-resistant Gram-negative organisms overwhelm hospitals worldwide, preservation of current antimicrobial treatment options becomes paramount in the face of dwindling development of novel antibiotics. There is extensive data demonstrating that application of pharmacokinetic/pharmacodynamic principles improves the possibility of enhancing clinical and microbiological outcome. There is expanding evidence demonstrating that unfavorable clinical outcomes and antimicrobial resistance may be suppressed when specific pharmacokinetic/pharmacodynamic targets are attained for beta-lactam and carbapenem antibiotics. This paper highlights pertinent studies that contribute to the principles and application of these principles.


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