alexa Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist
ISSN: 2168-975X

Brain Disorders & Therapy
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Case Report

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist

Maccaferri GE1, Rossetti AO2, Dalmau J34 5 and Berney A1

1Psychiatric Liaison Service, Lausanne University Hospital (CHUV), Switzerland

2Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Switzerland

3August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Service of Neurology, Hospital Clinic, University of Barcelona, Spain

4Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

4Department of Neurology, University of Pennsylvania, PA, USA

Corresponding Author:
Giorgio E Maccaferri, MD
Service de Psychiatrie de liaison
Département de Psychiatrie-CHUV
Les Allières 23, Av. de Beaumont 23
CH-1011 Lausanne, Switzerland,
Tel: +412131428 99
Fax: +41213145539
E-mail: [email protected]

Received Date: March 23, 2016; Accepted Date: May 07, 2016; Published Date: May 10, 2016

Citation: Maccaferri GE, Rossetti AO, Dalmau J, Berney A (2016) Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist. Brain Disord Ther 5:215. doi:10.4172/2168-975X.1000215

Copyright: © 2016 Maccaferri GE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a relatively newly identified autoimmune neuropsychiatric disorder that predominantly affects children and young adults. Although psychiatric symptoms are highly prevalent and frequently severe, it has mainly been reported in neurological, but not psychiatric, literature. Understanding this form of encephalitis, its quick diagnosis and which treatment to provide are of utmost importance for consultation-liaison (C-L) psychiatrists. The aim of this paper was to describe a case of anti-NMDAR encephalitis with severe psychiatric manifestations, who showed impressive recovery but required intensive involvement of the C-L psychiatry team. We emphasise the behavioural aspects, psychiatric symptoms and challenges faced by the CL consultant across the different phases of the treatment.

Methods: We report the different treatment phases for a young woman with anti-NMDAR encephalitis who developed severe neuropsychiatric symptoms, with a focus on the role and challenges faced by the C-L psychiatrist. The literature is reviewed for each of these challenges.

Results: This case illustrated that even extremely severely affected patients may show impressive recovery, but require long lasting psychiatric care. C-L psychiatrists are faced with numerous challenges where only little literature is available.

Conclusion: C-L psychiatrists play a pivotal role throughout the multidisciplinary care of patients with anti-NMDAR encephalitis and should be informed about this entity.


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