Case Report
Antinociceptive, Sedative and Muscle Relaxants Activity of Caralluma tuberculata N E Brown
Abdur Rauf1*, Naveed Muhammad2, Barkatullah3, Haroon Khan4, Hira Fatima Abbas5, Ajmal Khan5, Mohammad Arfan1 and Ghias Uddin1
1Institute of Chemical Sciences, University of Peshawar, Peshawar, KPK, Pakistan
2Department of Pharmacy, Abdul Wali Khan University Mardan, KPK, Paksitan
3Department of Botany, University of Peshawar, Peshawar, Pakistan
4Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan
5H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
- *Corresponding Author:
- Abdur Rauf
Institute of Chemical Sciences
University of Peshawar
Peshawar, KPK, 25120, Pakistan
Tel: +923469488944, +923139488944
E-mail: [email protected]
Received Date: August 27, 2013; Accepted Date: October 10, 2013; Published Date: October 17, 2013
Citation: Rauf A, Muhammad N, Barkatullah, Khan H, Abbas HF et al (2013) Antinociceptive, Sedative and Muscle Relaxants Activity of Caralluma tuberculata N E Brown. Orthop Muscul Syst 2: 131. doi: 10.4172/2161-0533.1000131
Copyright: © 2013 Rauf A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The current study was designed to assess the preliminary antinociceptive, sedative and muscle relaxants activates of crude extract and various solvent fractions of Caralluma tuberculata using established in-vivo protocols. The results illustrated significant (P<0.05) antinociceptive activity of extract/fractions of the plant in a dose dependent manner (50 and 100 mg/kg i.p.). When studied in open field test, the extracts and fractions of the plant demonstrated significant (P<0.05) sedative effect. Similarly, the extracts and fractions had (P<0.05) muscle relaxant effect on traction test. However, hexane was the only fraction which did not exhibit significant activity in either of the tests. The current investigation, suggest that Caralluma tuberculata contain potential molecules with antinociceptive, seadtive and muscle relaxant activities.
