alexa Antioxidant, Antimicrobial, Cytotoxic and Anticholinesterase Activities of SevenMushroom Species with their Phenolic Acid Composition | OMICS International
ISSN: 2376-0354

Journal of Horticulture
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Research Article

Antioxidant, Antimicrobial, Cytotoxic and Anticholinesterase Activities of SevenMushroom Species with their Phenolic Acid Composition

Abdurrahman Dundar1*, Veysi Okumus2, Sadin Ozdemir2, Kadir Serdar Celik3 Mehmet Boga4, Eren Ozcagli5, Gul Ozhan5 and Abdunnasir Yildiz6
1Mardin Artuklu University, Health Services Vocational High School, Department of Medicinal Promotion and Marketing, 47000, Mardin, Turkey
2Siirt University, Faculty of Science and Arts, Department of Biology, 56100, Siirt, Turkey
3Batman University, Faculty of Science and Arts, Department of Chemistry, Batman, Turkey
4Dicle University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 21280 Diyarbakir, Turkey,
5Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 34116, Beyazit, Istanbul Turkey
6Dicle University, Faculty of Science, Department of Biology, 21280, Diyarbakir, Turkey
Corresponding Author : Abdurrahman Dundar
Mardin Artuklu University, Health Services
Vocational High School, Department of Medicinal
Promotion and Marketing, 47000, Mardin, Turkey
Tel: +905058741149
Email: [email protected]
Received: September 22, 2015 Accepted: September 28, 2015 Published: September 30, 2015
Citation: Dundar A, Okumus V, Ozdemir S, Celik KS, Boga M, et al. (2015) Antioxidant, Antimicrobial, Cytotoxic and Anticholinesterase Activities of Seven Mushroom Species with their Phenolic Acid Composition. J Horticulture 2:161. doi:10.4172/2376-0354.1000161
Copyright: © 2015 Abdurrahman Dundar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The study focused to evaluate cytotoxic, antioxidant, antimicrobial and anticholinesterase activities of methanol extracts of Pleurotus ostreatus Jacq. (Pleurotaceae), Boletus edulis Bull. (Boletaceae), Tricholoma populinum J. (Tricholomataceae) Helvella queletii Bres. (Helvellaceae), Armillaria tabescens Emel. (Physalacriaceae), Psathyrella candolleana Fr. (Psathyrellaceae) and Helvella leucopus Pers. (Helvellaceae) mushroom species. Phenolic acid profiles of these mushrooms were also determined to obtain further information on the correlation between the contents of phenolic compounds and studied activities. Cytotoxic activity of mushrooms was screened by MTT cytotoxicity assay on cancer (HeLa) and normal epithelium (NRK-52E) cell lines. To determine antioxidant potential of mushroom extracts free radical scavenging, reducing power, superoxide anion radical scavenging, total antioxidant and metal chelating activities were studied, To indicate anthicholinesterase activity the acetyl-and butyrylcholinesterase inhibitory activities of the mushroom extracts were studied. For antimicrobial activity disc diffusion method was applied. Phenolic profile of mushrooms were determined by HPLC system. The IC50 values of the extracts were 1.58-25.11 and 2.05-22.32 mg/mL for HeLa and NRK-52E cells, respectively. At antimicrobial activity the inhibiton zones were found to be as 1 ± 0.12-13 ± 0.23 mm. P. ostreatus, B. edulis and H. leucopus extracts were showed higher activities than the other mushroms at antioxidant, antimicrobial, anticholinesterase and cytotoxic activity.

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