Antioxidant Therapy: Is it your Gateway to Improved Cardiovascular Health?M Ruhul Abid* and Frank W Sellke
Cardiovascular Research Center, Department of Surgery, Rhode Island Hospital, Brown University Warren Alpert Medical School, Providence, RI, USA
- *Corresponding Author:
- Ruhul Abid
Division of Cardiothoracic Surgery
Cardiovascular Research Center, Rhode Island Hospital
Brown University Medical School, Providence, RI 02903, USA
E-mail: [email protected]
Received date: October 09, 2014; Accepted date: December 23, 2014; Published date: December 29, 2014
Citation: Abid MR, Sellke FW (2015) Antioxidant Therapy: Is it your Gateway to Improved Cardiovascular Health?. Pharm Anal Acta 6:323. doi: 10.4172/2153-2435.1000323
Copyright: © 2015 Abid MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
General use and popularity of over-the-counter supplemental antioxidants have rapidly spread all over the world and are believed to promote cardiovascular health and wellbeing. However, there is a paucity of information and lack of proof that physiological and above-physiological levels of oxidants do harm at the cellular and organismal levels. Instead, several reports demonstrated that reduction in Reactive Oxygen Species (ROS) did not improve vascular function. Interestingly, recent studies show that increased ROS levels play protective role in vascular endothelium and may improve coronary endothelial function. In the current review, we introduce the concept that increased ROS levels, often seen in association with cardiovascular disease, probably is an endothelial-way or ‘oxidative response’ to cope with vascular pathology.