alexa <p>Antioxidants Attenuate the Effects of Insulin Dependent Diabetes Mellitus on Sperm Quality</p> | OMICS International | Abstract
ISSN: 2167-7662

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Case Report

Antioxidants Attenuate the Effects of Insulin Dependent Diabetes Mellitus on Sperm Quality

Omu AE1*, Al-Bader MD2, Al-Jassar WF1, Al-Azemi MK1, Omu FE3, Mathew TC4 and Anim JT5
1Department of Obstetrics and Gynaecology, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait
2Department of Physiology, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait
3Department of PAAET, College of Nursing, Kuwait University, Kuwait
4Department of Anatomy, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait
5Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait
Corresponding Author : Omu AE
Department of Obstetrics and Gynaecology
Faculty of Medicine, HSC, Kuwait University
PO Box: 24923, Safat13110, Kuwait
Tel: 00965 2498 6458
Fax: 00965 5338906
E-mail: [email protected]
Received January 24, 2014; Accepted February 20, 2014; Published February 22, 2014
Citation: Omu AE, Al-Bader MD, Al-Jassar WF, Al-Azemi MK, Omu FE, et al. (2014) Antioxidants Attenuates the Effects of Insulin Dependent Diabetes Mellitus on Sperm Quality. Bioenergetics 3:113. doi:10.4172/2167-7662.1000113
Copyright: © 2014 Omu AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: The prevalence of Diabetes Mellitus has been increasing in an epidemic proportion worldwide and it is associated with impairment of sperm quality and cause infertility. The role of antioxidants therapy to improve human sperm quality has not been established.

Objective of study: To investigate the effect of antioxidants therapy on sperm quality in men with insulin dependent diabetes mellitus.

Materials and methods: Forty-five men with insulin dependent diabetes attending the andrology clinic, between January 2008 and December 2012 seen at the Maternity Hospital, Kuwait, form the subjects of this study. Thirty nondiabetic infertile men matched for age and duration of infertility formed the control group. The study protocol included initial pretherapy and post-therapy clinical evaluation of all the patients, semen analysis, hormone profile, glycosylated haemoglobin (HbA1C), Malonedialdehyde (MDA), lipid profile, Acridine orange denaturation of sperm for evaluation of sperm DNA fragmentation index and light and electron microscopy. The patients were administered Zinc, Selenium and vitamins E and C for three months and revaluated.

Results: Diabetes mellitus was associated with significantly impaired sperm motility (asthenozoospermia) compare to control (64% versus 36%) (P<0.05), normal sperm morphology (66% versus 52%) (p<0.05), higher HbA1C (9.6% versus 4.4%, P<0.05) and oxidative stress (MDA) (2.4 versus 1.4 nmol/L, P<0.01) and reduced antioxidant status. Antioxidant therapy significantly decreased glucose level, 18-40% p<0.05; HbA1c 9-29% p<0.05; MDA level 33-41%, P<0.01; and Sperm DNA Fragmentation index, 23-33%, p<0.01) and Increase in BuChE 21-40%, p<​0.05 and TAC, 27- 36%, p<0.05.

Conclusion: Diabetes mellitus particularly with poor glycemic control is associated with impaired sperm quality, involving oxidative stress in the pathogenesis. Antioxidant therapy has been shown to significantly improve the sperm quality.

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