Antioxidants: Potential Inducers of Gene Expression through CAMP Dependent Pathway
Samarth Tandon*, Aayush Kukreja, Amit Mishra and Archana Tiwari
School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya-Bhopal-462033-Madhya Pradesh, India
- Corresponding Author:
- Samarth Tandon
School of Biotechnology
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Bhopal-462033, Madhya Pradesh, India
E-mail id: [email protected]
Received Date: April 16, 2013; Accepted Date: August 07, 2013; Published Date: August 09, 2013
Citation: Tandon S, Kukreja A, Mishra A, Tiwari A (2013) Antioxidants: Potential Inducers of Gene Expression through CAMP Dependent Pathway. J Blood Disord Transfus S3:006. doi: 10.4172/2155-9864.S3-006
Copyright: © 2013 Tandon S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Antioxidants have played a pivotal role in the treatment of various diseases like cancer, diabetes, cardiovascular diseases. The major goal of this review is to hypothesize the treatment strategy by the use of antioxidants for correcting the molecular defects found in β-thalassemia major. In that vein, we are trying to determine the mechanism of action and the role of two most potent antioxidants viz. Lycopene and Betalain in correcting the molecular defects of β-thalassemia major. The strategy discussed here can be utilized for the purpose of treatment of molecular anomalies in β-thalassemia major, which is on the line of enhancing the γ-globin gene expression by augmenting the cAMP level in the erythroid cells.