Anti-pyretic Potential of Dichloromethanolic Root Extract of Clutia abyssinica in Wistar Albino Rats
Koech SC*, Sindani AV, Maoga JB, Ouko RO, Njagi NM and Ngugi MP
Department of Biochemistry and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya
- *Corresponding Author:
- Koech Samson Cheruiyot
Department of Biochemistry and Biotechnology
Kenyatta University, PO Box 43844-00100, Nairobi, Kenya
E-mail: [email protected]
Received Date: December 27, 2016; Accepted Date: December 30, 2016; Published Date: January 06, 2017
Citation: Koech SC, Sindani AV, Maoga JB, Ouko RO, Njagi NM, et al. (2017) Anti-pyretic Potential of Dichloromethanolic Root Extract of Clutia abyssinica in Wistar Albino Rats. Med Aromat Plants (Los Angel) 6:281. doi: 10.4172/2167- 0412.1000281
Copyright: © 2017 Koech SC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fever is a symptom that is associated with pathological processes in animal body. It is mostly presented in a number of infections and diseases. Although, fever is utilized by the immune system as a means of defense against infections and diseases, it lowers the quality of life. Since fever brings discomfort to the victims it requires medication. Synthetic drugs that are used to manage fever are inaccessible and are associated with adverse effects. Herbal medicines are deemed to be safe, have good efficacy and are assumed to have fewer side effects. C. abyssinica has been used traditionally by Kallenjin community to manage fever among other ailments. However, ethnomedicinal use of the C. abyssinica lacks scientific validation. The study was designed to determine the antipyretic potential of dichloromethane root extracts of C. abyssinica on turpentine-induced pyrexia in Wistar albino rat. Thirty Wistar albino rats aged 8-9 weeks and weighing 120-140 g were grouped into normal group, positive control, negative control and three experimental groups. The laboratory animals were administered with the dichloromethane root extract at 50, 100 and 150 mg/kg body weight. The dichloromethane root extract reduced the elevated rectal temperature between 0.68 and 3.34%, while the reference drug reduced between 3.32 and 4.96%. Qualitative phytochemical screening of the root extract showed the presences of various phytochemicals compounds associated with antipyretic activities. The present study demonstrated antipyretic potential of C. abyssinica in Wistar albino rats and thus the traditional use of the C. abyssinica was scientifically confirmed.