Anti-Sm and Anti-U1-RNP Antibodies: An Update
Received Date: Dec 07, 2016 / Accepted Date: Dec 10, 2016 / Published Date: Dec 20, 2016
From their discovery anti-Sm autoantibodies (Ab) have been associated with systemic lupus erythematosus (SLE), while anti-U1-RNP Ab detected alone are predominant in patients with mixed connective disease (MCTD). However, the identification of anti-Sm/U1-RNP Ab in a patient may be challenging, and usually requiring a two-step process including a screening step performed by indirect immunofluorescence (IIF) on HEp-2 cells showing a coarse speckled nuclear staining at an elevated level, followed by a confirmatory assay using specific antigens. The recent development of novel assays and the characterization of the target epitopes have been beneficial to improve the sensitivity for anti-Sm/U1-RNP Ab detection, but, in some cases, the necessity to use a different assay remains mandatory. Another recent and unexpected observation is related to the suspected role played by environmental and epigenetic factors in the induction of anti-Sm/U1-RNP Abs. Altogether, better knowledge regarding anti-Sm/U1- RNP Ab will undoubtedly provide improvements for the management and treatment of these patients.
Keywords: Systemic lupus erythematosus; Mixed connective disease; Autoantibodies; Anti-Sm; Anti-U1-RNP
Citation: Lemerle J, Renaudineau Y (2016) Anti-Sm and Anti-U1-RNP Antibodies: An Update. Lupus Open Access 1: e104.
Copyright: © 2016 Lemerle J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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