Antisperm Antibodies in Undescended Testis
|Batool Mutar Mahdi1*, Riyadh Mohamad Hasan2, Mohammed Abdul Mahdi AL-Kurtas3, Nahla Ghanim4, Leen Khalog Al-Galabi4 and Wafaa Hazim1|
|1Department of Microbiology, Al-Kindi College of Medicine, University of Baghdad, Iraq|
|2Department of Surgery, Al-Kindi College of Medicine, University of Baghdad, Iraq|
|3Department of Pathology, Al-Kindi College of Medicine, University of Baghdad, Iraq|
|4Immunological Laboratory, Teaching Laboratories, Medical city, Iraq|
|Corresponding Author :||Dr. Batool Mutar Mahdi
Department of Microbiology
Al-Kindi College of Medicine
University of Baghdad, AL-Nahda Square
E-mail: [email protected]
|Received June 25, 2012; Accepted September 11, 2012; Published September 18, 2012|
|Citation: Mahdi BM, Hasan RM, AL-Kurtas MAM, Ghanim N, Al-Galabi LK, et al. (2012) Antisperm Antibodies in Undescended Testis. J Clin Cell Immunol S10:002. doi:10.4172/2155-9899.S10-002|
|Copyright: © 2012 Mahdi BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: Undescended testis is the commonest genital malformation in boys. Men with a history of undescended testis have a reduced probability of fertility.
Aim of the study: To explore whether the development of anti-sperm antibodies and antitesticular autoantibodies might play a role in inhibiting the future fertility of cryptorchid boys. Histopathological and hormonal assessments were done for those patients.
Patients and methods: The study group consisted of 30 patients with undescended testis who underwent Sub dartous orchidopexy at The AL-Kindi Teaching Hospital and other private hospitals. Orchidopexy and histopathological studies were done for them. Hormonal assessment, antisperm and antitesticular autoantibodies assessment were done for them.
Results: The mean age of the orchiopexy patients was 12 ± 9.4 years. Histopathological study revealed testicular atrophy in 76.6% of the cases. Antitesticular autoantibodies were detected by direct immunofluorescence. Antisperm antibodies and hormonal assay in patients’ serum before and after operation illustrated no significant difference.
Conclusions: The late descent of a testicle into the scrotum may impair its development ending in reduced fertility because of histopathological changes (atrophy) already become apparent in the first few months of life. Development of antitesticular autoantibodies may contribute in this process because the ectopic position of testis that damage barrier. Therefore, hormonal and surgical treatments complement each other and should be provided before the child’s first birthday.