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Antitumor Activity of Polysaccharides and Saponin Extracted from Sea Cucumber | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Antitumor Activity of Polysaccharides and Saponin Extracted from Sea Cucumber

Xiurong Su1*, Caiyun Xu1, Yanyan Li1, Xiang Gao1, Yanru Lou2 and Jinfeng Ding1
1Faculty of Life Science and Biotechnology, Ningbo University, Fenghua Road, Ningbo, Zhejiang Province 315211, P.R China
2Key Laboratory of Ningbo No.1 Hospistal, Liuting Street, Ningbo, Zhejiang Province 315010, P.R China
Corresponding Author : Xiurong Su
Faculty of Life Science and Biotechnology
Ningbo University, Fenghua Road, Ningbo City
Zhejiang Province 315211, P. R. China
Tel: 86-574-87608368
Fax: 86-574-87608368
E-mail: [email protected]
Received November 21, 2010; Accepted February 21, 2011; Published February 23, 2011
Citation: Su X, Xu C, Li Y, Gao X, Lou Y, et al. (2011) Antitumor Activity of Polysaccharides and Saponin Extracted from Sea Cucumber. J Clin Cell Immunol 2:105. doi:10.4172/2155-9899.1000105
Copyright: © 2011 Su X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The density gradient of S180 cells were treated with various extracts at a concentration of polysaccharides (P1 and P2) and saponins (S1 and S2) measured after 22h, 44h, 68h and 92 h post-treatment. P1, P2, and saponin S1 were extracted from Acaudina leucoproct, and S2 was extracted from the concentrated liquid of Stichopus japonica. The cytotoxic effects of S1 and S2 on S180 cells was demons treated dose and time dependent, using MTT assay. Saponin S2 exhibited the highest potency against S180 cells, with an IC50 of 41.04 µg/ml at 44 h. Additionally, by Annexin V/PI staining, we observed more viable cells under polysaccharides treatment compared to the saponins. These results indicate that the in vitro anti-tumor effects of saponins S1 and S2 are more potent than those of polysaccharides P1 and P2.