Anti-Ulcer Activity of Hingu Chooranam against Aspirin and Pylorus Ligation Induced Gastric Ulcer in Rats
In this modern era, gastrointestinal disorders are the universal problem. Peptic ulcer is one of the major diseases affecting the human population. It develops due to the imbalance between aggressive factors like acid, pepsin, H. pylori and bile salts and defensive factors like mucous, bicarbonate, blood flow, epithelial cell restoration and prostaglandins. The anti-ulcer activity of Hingu Chooranam (HC) was evaluated by using the experimental models of acute gastric lesions induced by aspirin and pylorus ligation in rats. Animals pre-treated with doses of 100 mg/kg and 200 mg/kg of HC were statistically analyzed and compared to the standard and control group with the parameters like volume of gastric secretion, PH, free acidity, total acidity and ulcer index. The results suggested that the HC significantly decreased the volume of gastric acid secretion, free acidity, total acidity and ulcer index in comparison with standard drug Ranitidine. HC shown significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in aspirin induced ulcer in experimental models. The gastric mucosal protective effect of HC is brought by inhibiting the gastric secretion, which shows it may act like a proton pump inhibitor. Further, the anti ulcer activity of HC which reduced gastric volume and total acidity in pylorus ligation ulcer model reveals that HC may act as a H2 receptor antagonist. Thus the present study indicates that HC has anti-ulcerogenic potency in aspirin induced and pylorus ligation induced ulcers in rats.