alexa Apical Variant of Hypertrophic Cardiomyopathy and Systemic Scleroderma- A Hint for Autoimmune Mechanism? | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Case Report

Apical Variant of Hypertrophic Cardiomyopathy and Systemic Scleroderma- A Hint for Autoimmune Mechanism?

Kalkidan Bishu1*, Jackson J. Liang2 and Nandan S. Anavekar3
1Fellow, Cardiovascular Division, Department of Medicine, Mayo Clinic, Rochester, USA
2Resident, Department of Medicine, Mayo Clinic, Rochester, USA
3Consultant, Cardiovascular Division, Department of Medicine, Mayo Clinic, Rochester, USA
Corresponding Author : Kalkidan Bishu, M.D
Mayo Clinic Cardiovascular Division
200 First Street SW, Rochester, Minnesota 55905, USA
Tel: 206-353-2176
E-mail: [email protected]
Received: May 20, 2012; Accepted: June 13, 2012; Published: June 15, 2012
Citation: Bishu K, Liang JJ, Anavekar NS (2012) Apical Variant of Hypertrophic Cardiomyopathy and Systemic Scleroderma- A Hint for Autoimmune Mechanism? J Clin Exp Cardiolog 3:199. doi:10.4172/2155-9880.1000199
Copyright: © 2012 Bishu K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

We present a 75-year-old female, Ms. W, with systemic scleroderma and Hypertrophic Cardiomyopathy (HCM) who was evaluated for one-year history of swelling in her ankles and feet. Cardiac auscultation revealed a left lower sternal border ejection systolic murmur that increased with Valsalva maneuver. ECG was consistent with Left Ventricular (LV) hypertrophy whereas transthoracic echocardiogram and cardiac MRI revealed increased LV wall thickness with asymmetric involvement of the apex and circumferential pericardial effusion. Although genetic mutations of cardiomyocyte sarcomeric proteins have been implicated in HCM, screening in several HCM cohorts have failed to identify genetic mutations in a substantial proportion of cases. A predisposition for HCM with certain human leukocyte antigen subtypes has been reported. In addition, an increased prevalence of HCM has been reported in chronic hepatitis C virus infection, a disease with multiple extra-hepatic autoimmune manifestations. Thus the occurrence of HCM in patients with autoimmune diseases such as systemic scleroderma may indicate potential autoimmune mechanism. Studies testing the hypothesis that autoimmune mechanisms are involved in producing the HCM phenotype, at least in patients with no identifiable genetic mutation affecting sarcomeric proteins, are needed.

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