alexa Apoptosis and the Developing T Cells
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Apoptosis and the Developing T Cells

Carolina Francelin and Liana Verinaud*
Department of Anatomy, Cell Biology and Physiology and Biophysics; Institute of Biology; State University of Campinas - UNICAMP; Campinas, São Paulo, Brazil
Corresponding Author : Liana Verinaud
Departamento de Anatomia, Biologia Celular e Fisiologia – UNICAMP
Cidade Universitária Zeferino Vaz s/n
CEP: 13084-970, Campinas – São Paulo – Brasil
E-mail: [email protected]
Received October 03, 2011; Accepted December 08, 2011; Published December 09, 2011
Citation: Francelin C, Verinaud L (2011) Apoptosis and the Developing T Cells. J Clin Cell Immunol S3:001. doi:10.4172/2155-9899.S3-001
Copyright: © 2011 Francelin C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Efficient TCR repertoire selection in the thymus is critical for immune function, ensuring the production of functional MHC-restricted and self-tolerant T cells. T cell education in the thymus involves positive and negative selection processes where apoptosis play an especially important role in eliminating useless or potentially dangerous thymocytes. For decades, positive and negative selection in T cell development has attracted the attention and considerable research has been conducted to improve our understanding of how ligand induced signaling through the T cell receptor (TCR) can lead to both: rescue from death in the case of positive selection and death in the case of negative selection. In this brief report, we review the basic concepts involved in the extrinsic and intrinsic pathway of apoptosis, and provide an overview of the events that leads immature T cells to survive or die by apoptosis during their intrathymic development.


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