alexa Apoptosis and the Developing T Cells
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Apoptosis and the Developing T Cells

Carolina Francelin and Liana Verinaud*
Department of Anatomy, Cell Biology and Physiology and Biophysics; Institute of Biology; State University of Campinas - UNICAMP; Campinas, São Paulo, Brazil
Corresponding Author : Liana Verinaud
Departamento de Anatomia, Biologia Celular e Fisiologia – UNICAMP
Cidade Universitária Zeferino Vaz s/n
CEP: 13084-970, Campinas – São Paulo – Brasil
E-mail: [email protected]
Received October 03, 2011; Accepted December 08, 2011; Published December 09, 2011
Citation: Francelin C, Verinaud L (2011) Apoptosis and the Developing T Cells. J Clin Cell Immunol S3:001. doi:10.4172/2155-9899.S3-001
Copyright: © 2011 Francelin C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

Efficient TCR repertoire selection in the thymus is critical for immune function, ensuring the production of functional MHC-restricted and self-tolerant T cells. T cell education in the thymus involves positive and negative selection processes where apoptosis play an especially important role in eliminating useless or potentially dangerous thymocytes. For decades, positive and negative selection in T cell development has attracted the attention and considerable research has been conducted to improve our understanding of how ligand induced signaling through the T cell receptor (TCR) can lead to both: rescue from death in the case of positive selection and death in the case of negative selection. In this brief report, we review the basic concepts involved in the extrinsic and intrinsic pathway of apoptosis, and provide an overview of the events that leads immature T cells to survive or die by apoptosis during their intrathymic development.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords