Apoptosis Induction By Cytosolic RNA HelicasesTobias Haas* and Hendrik Poeck
Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany
- *Corresponding Author:
- Tobias Haas
Klinikum rechts der Isar
Technische Universität München
81675 München, Germany
E-mail: [email protected]
Received date: August 22, 2012; Accepted date: September 27, 2012; Published date: September 29, 2012
Citation: Haas T, Poeck H (2012) Apoptosis Induction by Cytosolic RNA Helicases. J Med Microb Diagn 2:117. doi:10.4172/2161-0703.1000117
Copyright: © 2012 Haas T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Host protection against viruses depends on mounting an effective innate and adaptive immune response. Aside from the production of type I interferon and inflammation activation, a third line of defense against viral infections is the induction of programmed cell death (apoptosis) in infected cells. Recent work has uncovered essential roles for the cytoslic RNA helicases RIG-I and MDA-5 in the induction of apoptosis in diverse cell types. Here we discuss the mechanisms of RLR-induced programmed cell death as a mechanism of antiviral defense.