alexa Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer

Faisal F. Y. Radwan1, J. Manuel Perez2 and Azizul Haque1*
1Department of Microbiology and Immunology, Hollings Cancer Center, and Children’s Research Institute, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425
2Nanoscience Technology Center, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA
Corresponding Author : Dr. Azizul Haque
Department of Microbiology and Immunology
Medical University of South Carolina, 173 Ashley Avenue
BSB-201, Charleston, SC 29425, USA
Tel: +1-843-792-9466
Fax: +1-843-792-2464
E-mail: [email protected]
Received August 17, 2011; Accepted December 11, 2011; Published December 12, 2011
Citation: Radwan FFY, Perez JM, Haque A (2011) Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer. J Clin Cell Immunol S3:004. doi:10.4172/2155-9899.S3-004
Copyright: © 2011 Radwan FFY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Considering the fact that a key factor in tumor development is the evasion of immune detection, the search for natural products, which have reduced toxicity towards normal tissues as well as immunostimulatory capabilities has received growing interest. One attractive source of antitumor products is the Ganoderma lucidum mushroom, which has been used for centuries as an herbal medicine for the prevention and treatment of a variety of diseases, including cancer, and has been shown to improve immune function. Interestingly, its methanol soluble triterpenoid extracts, namely Ganoderic Acids (GAs), have been the subject of several recent investigations on their chemotherapeutic effects. While current research has revealed GAs\' role in inducing apoptosis of cancer cells with a much lower toxicity to healthy cells, little information is available on their in vitro and/or in vivo immune activities. In this review, we aim to discuss the current knowledge on GAs, and their potential as apoptosis inducing as well as immune activating molecules that could be a potential alternative approach for designing novel chemoimmunotherapeutics against malignant diseases. We also discuss other new approaches for exploiting the advantages of using a nanoparticle polymer-GA conjugate as a tool for a sustained and targeted delivery of drug in vivo.

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