alexa Application of Capillary Isotachophoresis in Phenothiazines Determination | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Application of Capillary Isotachophoresis in Phenothiazines Determination

Marzanna Kurzawa*, Anna Filipiak-Szok, Aneta Jastrzebska and Edward Szlyk

Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin str., 87-100 Torun, Poland

*Corresponding Author:
Marzanna Kurzawa
Department of Chemistry, Nicolaus Copernicus University
7 Gagarin str., 87-100 Torun, Poland
Tel: +48-56-611-43-69
Fax: +48-56-654-24-77
E-mail: [email protected]

Received date: Septemer 28, 2012; Accepted date: October 10, 2012; Published date: October 12, 2012

Citation: Kurzawa M, Filipiak-Szok A, Jastrzebska A, Szlyk E (2012) Application of Capillary Isotachophoresis in Phenothiazines Determination. Pharmaceut Anal Acta 3:173. doi: 10.4172/2153-2435.1000173

Copyright: © 2012 Kurzawa M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A capillary isotachophoretic method (cITP) using three electrolyte systems for determination of promethazine, thioridazine and chlorpromazine hydrochlorides in pharmaceutical preparations was demonstrated. Proposed systems were characterised by linearity range 5-100 mg/L with R2 in all cases were higher than 0.999. The elaborated method was tested on pharmaceutical preparations. The recovery values were from 96.5% to 101.3%. The proposed isotachophoretic method is simple with acceptable precision and accuracy and can be suitable for routine analysis of studied biological active compounds.

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