Application of Capillary Isotachophoresis in Phenothiazines DeterminationMarzanna Kurzawa*, Anna Filipiak-Szok, Aneta Jastrzebska and Edward Szlyk
Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin str., 87-100 Torun, Poland
- *Corresponding Author:
- Marzanna Kurzawa
Department of Chemistry, Nicolaus Copernicus University
7 Gagarin str., 87-100 Torun, Poland
E-mail: [email protected]
Received date: Septemer 28, 2012; Accepted date: October 10, 2012; Published date: October 12, 2012
Citation: Kurzawa M, Filipiak-Szok A, Jastrzebska A, Szlyk E (2012) Application of Capillary Isotachophoresis in Phenothiazines Determination. Pharmaceut Anal Acta 3:173. doi: 10.4172/2153-2435.1000173
Copyright: © 2012 Kurzawa M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A capillary isotachophoretic method (cITP) using three electrolyte systems for determination of promethazine, thioridazine and chlorpromazine hydrochlorides in pharmaceutical preparations was demonstrated. Proposed systems were characterised by linearity range 5-100 mg/L with R2 in all cases were higher than 0.999. The elaborated method was tested on pharmaceutical preparations. The recovery values were from 96.5% to 101.3%. The proposed isotachophoretic method is simple with acceptable precision and accuracy and can be suitable for routine analysis of studied biological active compounds.