alexa Application of Carbon Nanotube-Graphite Mixture for the Determination of Diclofenac Sodium in Pharmaceutical and Biological Samples
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Application of Carbon Nanotube-Graphite Mixture for the Determination of Diclofenac Sodium in Pharmaceutical and Biological Samples

Abdolmajid Bayandori Moghaddam1, Ali Mohammadi2,3* and Mozhgan Fathabadi2,4

1Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11155-4563, Tehran, Iran

2Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

3Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, P.O. Box 14155-6451, Iran

4Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Ali Mohammadi
Department of Drug and Food Control
Faculty of Pharmacy
Tehran University of Medical Sciences
Tehran, Iran
E-mail: [email protected]

Received Date: July 02, 2012; Accepted Date: July 14, 2012; Published Date: July 18, 2012

Citation: Moghaddam AB, Mohammadi A, Fathabadi M (2012) Application of Carbon Nanotube-Graphite Mixture for the Determination of Diclofenac Sodium in Pharmaceutical and Biological Samples. Pharmaceut Anal Acta 3:161. doi: 10.4172/2153-2435.1000161

Copyright: © Moghaddam AB, Mohammadi A, Fathabadi M (2012) Application of Carbon Nanotube-Graphite Mixture for the Determination of Diclofenac Sodium in Pharmaceutical and Biological Samples. Pharmaceut Anal Acta 3:161.

 

Abstract

In this study, the main purpose is to fabricate a sensitive and selective electrochemical sensor through the multiwalled carbon nanotube-graphite/Ag electrode (MWCNTs-G/Ag). The application of this sensor was developed for the determination of diclofenac sodium in pharmaceutical dosage form, urine and human plasma. MWCNTs-graphite mixture improved the electroactive surface area due to its porous structure and a remarkable increase in the peak currents was observed. It demonstrated a catalytic effect and speeded up the rate of redox process. Application of MWCNTs-G/Ag resulted in a sensitivity augmentation. It is found that a maximum current response for the sensor in the Britton-Robinson buffer solution can be obtained in pH 3. The prepared sensor showed good standard calibration curves during 3 consecutive days over the concentration range of 45-2000 ng/mL and RSD values ranging from 1.95–7.11%. The limit of quantitation and detection limit were 45 and 15 ng/mL, respectively.

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