Application of Fourier Function to Double Divisor Ratio Spectra Curves for Analysis of Some Amoebicide Drugs in Their Ternary MixturesNada S Abdelwahab* and Eglal A Abdelaleem
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Bani-Sueif University, Alshaheed Shehata Ahmad Hegazy St, 62514, Beni-Suef, Egypt
- *Corresponding Author:
- Dr. Nada S Abdelwahab
Pharmaceutical Analytical Chemistry Department
Faculty of Pharmacy, Bani-Sueif University
Alshaheed Shehata, Ahmad Hegazy St
62514, Beni-Suef, Egypt
Tel: 0117236884/ 0109059949
E-mail: [email protected]
Received date: January 04, 2012; Accepted date: February 20, 2012; Published date: February 22, 2012
Citation: Abdelwahab NS, Abdelaleem EA (2012) Application of Fourier Function to Double Divisor Ratio Spectra Curves for Analysis of Some Amoebicide Drugs in Their Ternary Mixtures. Pharm Anal Acta 3:148. doi: 10.4172/2153-2435.1000148
Copyright: © 2012 Abdelwahab NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This work concerns with development of spectrophotometric methods for analysis of Metronidazole, Diloxanide Furoate and Mebeverine HCl. Method (I) is double divisor ratio spectra derivative method (DDRD) which depends on using derivative signals of the ratio spectra using double divisor. Method (II) is hybrid double divisor ratio spectra (HDDR) which depends on convolution of the double divisor ratio spectra using trigonometric Fourier functions. The developed HDDR method showed better selectivity than DDRD due to its higher resolution power. The methods have been applied for analysis of the studied drugs in their commercial tablets and the results obtained from the analysis of the market sample by the proposed methods were statistically compared with those obtained by manufacturer RP-HPLC method.