alexa Applications of CRSIPR/Cas9 in Cancer Research

Cancer Medicine & Anti Cancer Drugs
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Review Article

Applications of CRSIPR/Cas9 in Cancer Research

Junming Yue1*, Ziyun Du1, Fu-Ming Zhou2, Peixin Dong3 and Lawrence M Pfeffer1

1Department of Pathology and Laboratory Medicine, USA

2Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA

3Department of Women’s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 0608638, Japan

*Corresponding Author:
Junming Yue, PhD
Center for Cancer Research
University of Tennessee Health Science Center
19 S. Manassas St., Memphis, TN 38163, USA
Tel: 1-901-448-2091
E-Mail: [email protected]

Received date: January 14, 2016 Accepted date: February 10, 2016 Published date: February 15, 2016

Citation: Yue J, Du Z, Zhou FM, Dong P, Pfeffer LM (2016) Applications of CRSIPR/Cas9 in Cancer Research. Cancer Med Anticancer Drug 1:103.

Copyright: © 2016 Yue J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.

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