Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A ReviewAlex S. Huang1,2*, Chirayu Mohindroo1 and Robert N. Weinreb3
- *Corresponding Author:
- Alex Huang, MD/PhD
Doheny Eye Institute, Department of Ophthalmology
David Geffen School of Medicine
University of California, Los Angeles
1355 San Pablo Street, Los Angeles
CA 90033, USA
Email: [email protected]
Received date: April 28, 2016; Accepted date: July 21, 2016; Published date: July 24, 2016
Citation: Huang A, Mohindroo C, Weinreb RN (2016) Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review. J Clin Exp Ophthalmol 7:578. doi: 10.4172/2155-9570.1000578
Copyright: © 2016 Huang AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. AHO investigation can be divided into structural and functional assessments using different methods. The historical basis for studying the anterior segment of the eye and AHO in glaucoma is discussed. Structural studies of AHO are reviewed and include traditional pathological approaches to modern tools such as multi-model two-photon microscopy and optical coherence tomography. Functional assessment focuses on visualizing AHO itself through a variety of non-real-time and real-time techniques such as aqueous angiography. Implications of distal outflow resistance and segmental AHO are discussed with an emphasis on melding bench-side research to viable clinical applications. Through the development of an improved structure: function relationship for AHO in the anterior segment of the normal and diseased eye, a better understanding of the eye with improved therapeutics may be developed.