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Are all Glioma Cells Cancer Stem Cells? | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Research Article

Are all Glioma Cells Cancer Stem Cells?

Cruz Mabel1, Siden Åke1,2, Tasat Deborah Ruth3 and Yakisich J. Sebastian1*

1Department of Clinical Neuroscience R54, Karolinska Institute, Stockholm, Sweden

2Department of Neurology, Karolinska University Hospital, Stockholm, Sweden

3Universidad Nacional de San Martín Buenos Aires, Argentina

*Corresponding Author:
Dr. Yakisich J. Sebastian, Ph.D.,
Department of Clinical Neuroscience,
Karolinska University Hospital,
Stockholm, Sweden,
Tel: +46 8 585 89 533,
Fax: +46 8 585 83810,
E-mail: [email protected]

Received Date: May 06, 2010; Accepted Date: June 16, 2010; Published Date: June 16, 2010

Citation: Cruz M, Siden Å, Tasat DR, Yakisich JS (2010) Are all Glioma Cells Cancer Stem Cells? J Cancer Sci Ther 2: 100-106. doi: 10.4172/1948-5956.1000032

Copyright: © 2010 Cruz M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The cancer stem cell theory proposes that there is a small but constant subpopulation of cancer cells with stem cell properties responsible for the self renewal capacity and unlimited proliferation of tumor as well as increased resistance to antineoplastic drugs. Targeting these cells might constitute an effective way to cure cancer. Regarding gliomas, by analysing proliferation kinetics of cultures containing mixed subpopulations and experimental data from literature on glioma cell lines, we propose a model (Stemness Phenotype Model) in which all glioma cells have stem cells properties but their phenotype varies depending on the environmental conditions. This model provides an alternative explanation to different and sometimes controversial experimental findings and might be a useful guide for future research in the field of gliomas and stem cell biology.

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