Gynecology & Obstetrics
Open Access

Abstract

Are beta2-Adrenergic Receptor Gene Single-Nucleotide Polymorphisms Associated with Polycystic Ovary Syndrome? a Pharmacogenetic Study

Jafarian T, Naghizadeh MM, Salmani A, Nejad Fathe Moghadam S and Zangeneh FZ

Study background: Polycystic ovary syndrome (PCOS) is a common complex condition in women associated with reproductive, metabolic and psychological features. Evidences from studies on women with PCOS and on an experimental rat PCO model suggest that the sympathetic regulatory drive to the ovary may be unbalanced (hyperactivity). The aim of this study was to investigate polymorphism codon 16, 27,113 and 164 of beta2 adrenergic receptor in polycystic ovary syndrome (PCOS).

Methods: 100 patients with PCOS from Infertility Center of Valie Asre, Imam Khomeini Hospital Complex participated in this study for the first time between May 2014-2015. All women aged 20-40 years and had a body mass index (BMI) were under 28.

Results: Our results show that women with PCOS had polymorphism only in codon 164 with 44.4% (P< 0.002), that represents a significant difference between the study and control groups.

Conclusion: Therefore Beta2 adrenergic receptor gene polymorphism (Thr164Ile) associates withpolycystic ovary syndrome. The ratio of heterozygotes to homozygotes shows a significant difference between the two groups.