Are Placental Cell-Derived Exosomes a Predictive Biomarker of Preeclampsia?
Alexander E Berezin*
Senior Consultant of Therapeutic Unit, Internal Medicine Department, State Medical University of Zaporozhye, 26, Mayakovsky av., Zaporozhye, Ukraine
- *Corresponding Author:
- Alexander E Berezin
Senior Consultant of Therapeutic Unit
Internal Medicine Department
State Medical University of Zaporozhye
26, Mayakovsky av., Zaporozhye, Ukraine
E-mail: [email protected] (or) [email protected]
Received Date: June 09, 2017 Accepted Date: June 13, 2017 Published Date: June 15, 2017
Citation: Berezin AE (2017) Are Placental Cell-Derived Exosomes a Predictive Biomarker of Preeclampsia? Med Chem (Los Angeles) 7: 186-187. doi: 10.4172/2161-0444.1000454
Copyright: © 2017 Berezin AE. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Placenta is endocrine organ that regulate biological function of several maternal tissues and fetal organs by specific mechanisms of cell-to-cell cooperation, which is realized via exosomes’ secretion. Exosomes delivery some molecules, i.e., active proteins, pro-coagulants, growth factors, lipids, enzymes, micro-RNAs to target cells and induce autocrine / paracrine effects on vasculature and trophoblast. Interestingly, circulating number of exosomes derived from placenta cells in healthy pregnancies increases in 50-100 fold times to healthy volunteers and they may be detected in several biological fluids across all gestation age starting with 6 weeks of gestation. Moreover, pregnancies at risk of preeclampsia exhibit extremely increased levels of total exosomes and placental cell-derived-exosomes in blood when compared with woman at risk free of preeclampsia. Taking into consideration this fact, measure of circulating number of placental cell-derived-exosomes could be an individual probe for personification of a risk of life-threatening event across pregnancy. The short communication is depicted the role of placental cell-derived-exosomes as biomarker of preeclampsia in asymptomatic pregnancies.