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ISSN: 2329-6917

Journal of Leukemia
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Review Article

Are Survivors of Childhood Acute Lymphoblastic Leukemia at Increased Risk for Low Bone Mass?

Adriana Aparecida Siviero Miachon1, Maria Lucia de Martino Lee2, Gil Guerra-Junior3 and Angela Maria Spinola-Castro1*

1Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of Sao Paulo, Brazil

2Pediatric Oncology Institute, Sao Paulo, Brazil

3Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas, Brazil

*Corresponding Author:
Angela Maria Spinola-Castro
Division of Pediatric Endocrinology, Department of Pediatrics
Federal University of Sao Paulo - UNIFESP/EPM
307 Doutor Diogo de Faria Street, ZIP: 04037-000, Sao Paulo, Brazil
Tel: +55 11 5579-9409
E-mail: [email protected]

Received date: May 28, 2014; Accepted date: August 12, 2014; Published date: August 26, 2014

Citation: Siviero Miachon AA, Lucia de Martino Lee M, Guerra-Junior G, Spinola-Castro AM (2014) Are Survivors of Childhood Acute Lymphoblastic Leukemia at Increased Risk for Low Bone Mass?. J Leuk (Los Angel) 2:150. doi: 10.4172/2329-6917.1000150

Copyright: © 2014 Miachon AAS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Acute lymphoblastic leukemia is the most prevalent cancer in children. As an increasing number of cancer survivors reaches adulthood, there may be consequences of the treatment, and there is an issue if low bone mass might be included as a significant late effect. Acute lymphoblastic leukemia patients may have their bone mass compromised during therapy and many years after its withdrawal, but the degree of bone mass decline or recovery are not well elucidated to date. Survivors of stem cell transplantation for leukemia have additional risk factors for bone loss and should be evaluated with caution. Our target is to make a warning about the difficulties in assessing and interpreting bone mass in children and adolescents, the limitations in this assessment in acute lymphoblastic leukemia young survivors (including survivors of stem cell transplantation), the possibility of misdiagnoses, the reasons (if there are any) of low bone mass in this particular group of cancer survivors, as well as consider the therapeutic issues available.

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