alexa Articular Cartilage Injury Treatment: History and Basic Science Review | OMICS International | Abstract
ISSN: 2161-0533

Orthopedic & Muscular System: Current Research
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Research Article

Articular Cartilage Injury Treatment: History and Basic Science Review

Dumnoensun Pruksakorn1*, Peraphan Pothachareoun2, Kassisin Klunklin1, Puwapon Nimkingratana1, Sattaya Rojanastein1, Sompan Padongkiert1, Olarn Arpornchayanon1 and Prachya Kongtawelert2

1Musculoskeletal Research Division, Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Thailand, 50200

2Thailand Excellence Centre for Tissue Engineering, Department of Biochemistry, Chiang Mai University, Thailand, 50200

*Corresponding Author:
Dumnoensun Pruksakorn
Department of Orthopedics
Faculty of Medicine
Chiang-Mai University
Chiang-Mai, Thailand - 50200
Tel: 66- 53-945544
E-mail: [email protected]

Received Date: February 21, 2012; Accepted Date: June 11, 2012; Published Date: June 13, 2012

Citation: Pruksakorn D, Pothachareoun P, Klunklin K, Nimkingratana P, Rojanastein S (2012) Articular Cartilage Injury Treatment: History and Basic Science Review. Orthop Muscul Syst 1: 114. doi: 10.4172/2161-0533.1000114

Copyright: © 2012 Pruksakorn D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cartilage injury has been a troublesome problem for a long time; nevertheless the concepts of treatment have dramatically changed over the last two decades. Currently, three surgical principles have been used for cartilage resurfacing including marrow stimulating, osteochondral transplantation, and autologous chondrocyte implantation. Microfracture based on the traditional marrow stimulating technique is recommended in small (2-4 cm2) and well containable lesions in order to retain the marrow clot. The smaller and closer subchondral portals are necessary to concentrate the growth factors for controlling a good quality of new cartilage formation. Autologous osteochondral transplantation provides initial graft durability, and is recommended for very small lesions (< 2 cm2) because of the donor site morbidity concern. Osteochondral allograft transplantation allows an unlimited size of reparation; however chondrocyte apoptosis and extracellular matrix breakdown secondary to the long term preservation lead to graft degradation overtime. Autologous chondrocyte implantation repairs the cartilage defect based on two potential factors; chodrocytes and periosteum-derived progenitor cells. The interaction between cells balances the growth factors at the repairing site. The suitable mechanical stimuli and cell-matrix interactions also play a crucial role in cell proliferation, differentiation, cartilage tissue formation and integration to the surrounding host tissue.


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