alexa Artificial Antigen Presenting Cells: An Off the Shelf A
ISSN: 2169-0111

Advancements in Genetic Engineering
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Review Article

Artificial Antigen Presenting Cells: An Off the Shelf Approach for Generation of Desirable T-Cell Populations for Broad Application of Adoptive Immunotherapy

Hasan AN*1,2, Selvakumar A1 and O’Reilly RJ1,2,3
1Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, USA
2Bone Marrow Transplantation Service, Division of Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, USA
3Immunology Program, Sloan-Kettering Institute at Memorial Sloan-Kettering Cancer Center 1275 York Avenue, New York, NY 10021, USA
Corresponding Author : Aisha N. Hasan
Department of Pediatrics
Memorial Sloan-Kettering Cancer Center 1275 York Avenue
New York, NY 10021, USA
Tel: 212-639-3267
Fax: 212-717-3447
E-mail: [email protected]
Received: July 20, 2015 Accepted: September 29, 2015 Published: October 05, 2015
Citation: Hasan AN, Selvakumar A, O’Reilly RJ (2015) Artificial Antigen Presenting Cells: An Off the Shelf Approach for Generation of Desirable T-Cell Populations for Broad Application of Adoptive Immunotherapy. Adv Genet Eng 4:130. doi:2169-0111.1000130
Copyright: © 2015 Hasan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Adoptive transfer of antigen specific T-cells can lead to eradication of cancer and viral infections. The broad application of this approach has further been hampered by the limited availability of adequate numbers of T-cells for treatment in a timely manner. This has led to efforts for the development of efficient methods to generate large numbers of T-cells with specificity for tumor or viral antigens that can be harnessed for use in cancer therapy. Recent studies have demonstrated that during encounter with tumor antigen, the signals delivered to T-cells by professional antigen-presenting cells can affect T-cell programming and their subsequent therapeutic efficacy. This has stimulated efforts to develop artificial antigen-presenting cells that allow optimal control over the signals provided to T-cells. In this review, we will discuss the cellular artificial antigen-presenting cell systems and their use in T-cell adoptive immunotherapy for cancer and infections.

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