alexa Ascorbic Acid in Cancer: A Renewed Hope?
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Review Article

Ascorbic Acid in Cancer: A Renewed Hope?

Sunil Rangarajan1*, Bhuvana Sunil1 and Lisa M Curtis1,2

1Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, AL, USA

2Veterans Affairs Medical Center, Birmingham, AL, USA

*Corresponding Author:
Sunil Rangarajan
MBBS, 2nd Avenue South
LHRB 452, 1720 Birmingham
Alabama – 35294, University of Alabama at Birmingham
Tel: 205-934-5783
Fax: 205-975-6288
E-mail: [email protected]

Received date: May 06, 2014; Accepted date: August 28, 2014; Published date: September 03, 2014

Citation: Rangarajan S, Sunil B, Curtis LM (2014) Ascorbic Acid in Cancer: A Renewed Hope? J Cancer Sci Ther 6:333-336. doi:10.4172/1948-5956.1000291

Copyright: © 2014 Rangarajan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Ascorbic acid (AA), long known to treat scurvy, has had debatable use as an anti-neoplastic drug in the past. However recent in vitro and in vivo studies have revealed previously unexplored mechanisms through which AA selectively damages cancer cells without causing damage to normal cells. In view of newly emerging evidence, many clinical trials have been designed to study these effects in patients with different types of cancers. Promising results from these initial trials are giving renewed hope to the use of AA as an adjuvant to the conventional chemotherapeutic drugs to treat cancer, to alleviate toxicity from the treatment and to reduce patient morbidity.


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