alexa Assessment of Genetic Mutations in Genes DSM-IV, DRD4, SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2 and BDNF Induced Attention Deficit Disorder and Hyperactivity in Children
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Assessment of Genetic Mutations in Genes DSM-IV, DRD4, SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2 and BDNF Induced Attention Deficit Disorder and Hyperactivity in Children

Shahin Asadi1*, Mahsa Jamali2, Zahra Gholizadeh2, Mina Niknia2 and Maryam Safi2

1Research Center for Stem Cell and Drug Applied Research Center, Tabriz University of Medical Sciences in Modern Biology, Tabriz, Iran

2Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

*Corresponding Author:
Shahin Asadi
Student of Molecular Genetics
Research Center for Stem Cell and
Drug Applied Research Center
Tabriz University of Medical
Sciences in Modern Biology, Tabriz, Iran
Tel: +989379923364
E-mail: [email protected]

Received date: November 28, 2016; Accepted date: December 19, 2016; Published date: December 22, 2016

Citation: Asadi S, Jamali M, Gholizadeh Z, Niknia M, Safi M (2016) Assessment of Genetic Mutations in Genes DSM-IV, DRD4, SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2 and BDNF Induced Attention Deficit Disorder and Hyperactivity in Children. J Neurol Disord 4:324. doi:10.4172/2329-6895.1000324

Copyright: © 2016 Asadi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..

 

Abstract

In this study we have analyzed 1200 people, 580 ADHD and 620 control groups. The genes DSM-IV, DRD4, SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2 and BDNF analyzed in terms of genetic mutations made. In this study, people who have genetic mutations were targeted, with nervous disorders, ADHD. In fact, of all people with ADHD, 360 children had a genetic mutation in the genes DSM-IV, DRD4, SERT, and HTR1B. And 100 children had a genetic mutations in SNAP25, GRIN2A genes were a genetic mutations in the genes ADRA2A, TPH2 and BDNF and 70 children, respectively. Any genetic mutations in the target genes control group, did not show.

Hypothesis and objectives: In this study, we further understand the genes involved in ADHD children with the genetic mutations discussed. The aim of this study was to evaluate genetic and epigenetic closer to induce hyperactivity disorder in children.

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