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ISSN: 2168-9784

Journal of Medical Diagnostic Methods
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Research Article

Assessment of Screening Tests Used to Detect Toxoplasma gondii in Women in Sudan

Khalil Mohamed1*, Petr Kodym2, Marek Maly3 and Intisar EL Rayah4
1Commission for Biotechnology & Genetic Engineering, Department of Medical Biotechnology, Khartoum, Sudan
2National Institute of Public Health, National Reference Laboratory for Toxoplasmosis, Prague, Czech Republic
3National Institute of Public Health, Department of Biostatistics and Informatics, Prague, Czech Republic
4Tropical Medicine Research Institute TMRI, Khartoum, Sudan
Corresponding Author : Khalil Mohamed
Commission for Biotechnology & Genetic Engineering
Department of Medical Biotechnology
Khartoum, Sudan
E-mail: [email protected]
Received March 19, 2012; Accepted April 22, 2012; Published April 27, 2012
Citation: Mohamed K, Kodym P, Maly M, Rayah IEL (2012) Assessment of Screening Tests Used to Detect Toxoplasma gondii in Women in Sudan. J Med Diagn Meth 1:102. doi:10.4172/2168-9784.1000102
Copyright: © 2012 Mohamed K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Blood samples from 255 child bearing age women distributed into two villages named EL Nuba and EL Massoudia were collected according to their agreement and after obtaining their written consent form. Plasma separated from 255 blood samples were tested at delivery for Toxoplasma gondii antibodies using three different screening tests. These tests were Latex Agglutination Test (LAT), Complement Fixation Test (CFT), and ELISA IgG. Evaluation of the screening test was done for the three tests. The sensitivity of LAT, CFT, and ELISA IgG were 82.5%, 96.8%, and 98.9% respectively. The specificity of these tests was 91.2%, 94.1%, and 97.1% respectively. The Positive predictive value was 96.2%, 97.8%, and 98.9% respectively. The negative predictive value was 66%, 91.4% and 97.8%, respectively. The positive likelihood ratio was 9.35, 16.4, and 33.6 respectively. The negative likelihood ratio was 0.192, 0.0345, and 0.11 respectively. According to these evaluations a proposed protocol was drawn to detect infection in women.

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