Assessment of the Incidence of Neonatal Sepsis, its Risk Factors, Antimicrobials Use and Clinical Outcomes in Bishoftu General Hospital, Neonatal Intensive Care Unit, Debrezeit-Ethiopia
- *Corresponding Author:
- Minyahil Alebachew Woldu
Department of pharmacology and clinical pharmacy
College of health sciences, School of pharmacy
Addis Ababa University, P.O. Box 9086, Ethiopia
E-mail: [email protected]
Received Date: August 07, 2014; Accepted Date: September 08, 2014; Published Date: September 10, 2014
Citation: Woldu MA, Guta MB, Lenjisa JL, Tegegne GT, Tesafye G (2014) Assessment of the Incidence of Neonatal Sepsis, its Risk Factors, Antimicrobials Use and Clinical Outcomes in Bishoftu General Hospital, Neonatal Intensive Care Unit, Debrezeit-Ethiopia. Pediat Therapeut 4:214. doi:10.4172/2161-0665.1000214
Copyright: © 2014 Woldu MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: The incidence of neonatal sepsis (NS) varies from 6 to 9 cases per 1,000 live births, but is higher among low-birth-weight neonates. The purpose of the present study was to examine the risk factors, antimicrobial use pattern and clinical outcomes of NS.Methods: A prospective cross-sectional study was conducted using pretested and validated checklists. Results: Among the total 306 neonates 249(81.4%) were age less than or equal to 7days, and 169(55.23%) were male, while 251(82%) were attended antenatal care, 136 (44.44%) were low in birth weight (<2.5Kg) and155(50.7%) had total of white blood cell count >12000/mm3. Two hundred twenty one (72.2%) of the neonates were receive antibiotics for management of sepsis while 74 (24.2%) were receive antibiotics for other managements. The most frequently prescribed antibiotic was the combination of ‘ampicillin + gentamicin’ with 67(21.9%) followed by single antibiotic prescriptions of benzyl penicillin 33(10.8%) and cloxacillin 8(2.6%). A significant number of neonates (p=0.000) with 95% C.I of (1.934-8.967) were born in health center and developed sepsis. This value is 4.2 times higher when compared to the neonates born in home. A significant number of neonates born with the aid of instrument in hospitals were also developed sepsis (p=0.26). The risk of acquiring sepsis in neonates born with the aid of instruments was 6.2 times higher than children born vaginally in natural way. A significant number of neonates born from mothers’ with urinary tract infection (UTI) developed sepsis (p=0.02) and this figure was 2.9 times higher than neonates born from mothers’ with no UTI. Conclusions: In the present study, the most common risk factors for the incidence of neonatal sepsis were place of delivery, mode of delivery and mothers with UTI.