alexa Assessment of Toll-like Receptors in the Ileum of Weanling Pigs- Responses to Feed Antibiotic Chlortetracycline and Gnotobiotic Conditions
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Assessment of Toll-like Receptors in the Ileum of Weanling Pigs- Responses to Feed Antibiotic Chlortetracycline and Gnotobiotic Conditions

Sajan George1,4, Katherine Circle1, Stacy Lindblom2, Sebastien Vilain1, Artur J.M. Rosa2, David Francis3,4, Volker Brözel1,4 and Radhey S. Kaushik1,3,4*
1Departments of Biology & Microbiology, South Dakota State University, Brookings, SD-57007, USA
2Animal & Range Sciences, South Dakota State University, Brookings, SD-57007, USA
3Veterinary & Biomedical Sciences, South Dakota State University, Brookings, SD-57007, USA
4Center for Infectious Disease Research & Vaccinology, South Dakota State University, Brookings, SD-57007, USA
Corresponding Author : Radhey S. Kaushik
Department of Biology and Microbiology
SNP 252B, Box 2140D, Rotunda Lane
South Dakota State University, Brookings, SD 57007, USA
Tel: 605-688-5501
Fax: 605-688-5624
E-mail: [email protected]
Received June 29, 2012; Accepted July 31, 2012; Published August 06, 2012
Citation: George S, Circle K, Lindblom S, Vilain S, Rosa AJM, et al. (2012) Assessment of Toll-like Receptors in the Ileum of Weanling Pigs - Responses to Feed Antibiotic Chlortetracycline and Gnotobiotic Conditions. J Clin Cell Immunol 3:125. doi:10.4172/2155-9899.1000125
Copyright: © 2012 George S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

It has been suggested that changes in diet at weaning in pigs induce intestinal inflammation which may be mediated through toll-like receptors (TLRs). We hypothesized that the use of antibiotics as growth promoters and subsequent changes in intestinal microbiota may mediate changes in the expression of TLRs in the intestine. Thus, this study was performed to assess the changes in intestinal TLRs in weanling pigs in response to the use of chlortetracycline as a growth promotant, and under gnotobiotic conditions. Eighteen cesarean-derived half-sib piglets were divided into three groups; antibiotic-fed, control (normal-fed) and gnotobiotic groups.TLR-2, -4, -5 and -9 gene expression and abundance of TLR-2 and -9 proteins in the ileum of pigs was assessed at 5 wk of age. No significant differences (p ?0.5) in TLR-2, -4, -5 and -9transcript levels and abundanceof TLR-2 and -9 proteins among three groups of pigswere observed.

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