Assessment of Vitamin D Status in Egyptian Children with Type-1 Diabetes MellitusGamal Taha Soliman1, Basma Abdelmoez Ali1*, Ashraf Abdelfadeil Mohamed1, Ahmed Mohamed Mahmoud2 and Ahmed Abdelaziz Abdellatif1
- Corresponding Author:
- Basma Abdelmoez Ali
Professor of pediatrics, Faculty of Medicine, Minia University, Egypt
Tel: 002 0100 6227847; 002 0862352728
E-mail: [email protected]
Received Date: May 20, 2015; Accepted Date: June 22, 2015; Published Date: June 26, 2015
Citation: Soliman GT, Ali BA, Mohamed AA, Mahmoud AM, Abdellatif AA (2015) Assessment of Vitamin D Status in Egyptian Children with Type-1 Diabetes Mellitus. J Diabetes Metab 6:573. doi:10.4172/2155-6156.1000573
Copyright: © 2015 Soliman GT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Vitamin D and its active form are potent immune-modulators and are known to play an important role in the glucose/insulin metabolism. Studies on type 2 diabetes mellitus (T2DM) have shown that vitamin D increases insulin efficacy; However, there are no studies that define a similar relationship in type 1 diabetes mellitus (T1DM). Aim of the work: To evaluate serum vitamin D status in children with type 1 diabetes mellitus with comparison to healthy subjects and to correlate its level with different clinical and laboratory parameters. Subjects and methods: This study included two groups; Group I: included 53 patients with T1D; 43 patients with poor glycemic control (group Ia ) and 10 patients with good glycemic control (group Ib). Another 15 apparently ealthy children and adolescent?s age and sex matched to the diseased group were taken as a control group and classified as group II. The studied groups were subjected to thorough history taking, clinical examination and laboratory investigations including: fasting blood glucose, glycated hemoglobin (HbA1c %), serum calcium level and 25-hydroxyvitD level. A serum 25OHD level of < 10 ng/mL was accepted as vitamin D deficiency, whereas < 20 ng/ mL was accepted as vitamin D insufficiency. Results: Serum 25-hydroxyvitD and serum calcium levels were significantly lower in T1D children than the control and in group Ia than group Ib. 25-hydroxyvitD had a significant strong positive correlation with serum calcium and significant strong negative correlations with fasting blood sugar and HbA1c %. Conclusion: T1D children had significantly lower serum 25- hydroxyl vit D and serum calcium levels than the control group. Vitamin D in diabetic persons is an important factor in glycemic control with subsequent prevention of further complications.