Association among Systolic Blood Pressure Variation, Inflammation and Arterial Rigidity in Essential Hypertension
Yunfu Lv*, XiaoYu Han, Xiaoguang Gong, Wenbiao Gu, Chao He, Hongfei Wu, YeJuan Li and Jie Den
Department of General Surgery, Hainan Province People’s Hospital, Haikou 570311, China
- *Corresponding Author:
- Yunfu lv
Department of General Surgery
Hainan Province People’s Hospital
E-mail: [email protected]
Received Date: Septemebr 23, 2015; Accepted Date: October 31, 2015; Published Date: November 07, 2015
Citation: Yunfu Lv, Han XY, Gong X, Gu W, He C, et al. (2015) Analysis of Peripheral Blood Cells Due to Adults Posthepatitic Cirrhotic Portal Hypertension and Their Postoperative Prognosis. J Hypertens (Los Angel) 4:210. doi:10.4172/2167-1095.1000210
Copyright: © 2015 Yunfu Lv, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To assess the relationship among systolic blood pressure variation (BPV), inflammation and arterial rigidity in essential hypertension. Methods: This study enrolled 80 patients with essential hypertension, who were started on blood pressure control treatment with medications and lifestyle modification, and 18 normotensive healthy controls. At enrollment and 1-year follow-up, systolic BPV was evaluated by coefficient of variation (CV) in ambulatory blood pressure monitoring; arterial rigidity by brachial-ankle pulse wave velocity (ba-PWV) using ColinVP-1000; and inflammation by high-sensitivity plasma C-reactive protein (hs-CRP) level using rate nephelometry; electrocardiography, blood glucose, lipid profile, creatinine, blood urea nitrogen, and liver and renal function also were assessed. Results: There were no significant differences in demographics, clinical or biochemical profiles between patients and normotensive controls, except for blood pressure at enrollment but not 1-year follow-up, reflecting effectiveness of blood pressure control measures, with significant decreases in CV, ba-PWV and hs-CRP between enrollment and 1-year follow-up in hypertensive patients; change in CV significantly correlated with those in ba-PWV and hs-CRP (both P<0.001, adjusted by SBP d). Conclusion: The effect of systolic BPV on arterial rigidity could be mediated by its influence on the onset and progression of inflammation.